Research progress of driver gene alteration and targeted therapy for intrahepatic cholangiocarcinoma

Abstract

Abstract: Intrahepatic cholangiocarcinoma (ICCA) is a primary liver cancer originating from the intrahepatic bile duct epithelium, which is second only to hepatocellular carcinoma in terms of incidence and is extremely malignant with a 5-year overall survival rate of less than 10%. Surgery is the perferred radical treatment choice. Patients with advanced disease are resistant to radiotherapy or chemotherapy, the efficacy is unsatisfactory, and there is an urgent need to find new and effective treatment methods. With the advent of precision medicine, research on the mechanisms of multiple driver gene alterations and signaling pathway abnormalities in intrahepatic cholangiocarcinoma in China and abroad has been intensifying in recent years, and targeted therapy and immunotherapy have been more and more widely used in clinical practice. This paper is intended to review the research progress of driver gene alterations and targeted therapies for intrahepatic cholangiocarcinoma.

Key words: Intrahepatic cholangiocarcinoma, Driver genes, Targeted therapies

Zhang Shihui, Li Zhuo, Yihebali·Chi, Shi Susheng. Research progress of driver gene alteration and targeted therapy for intrahepatic cholangiocarcinoma[J]. Electronic Journal of Liver Tumor, 2023, 10(4): 15-22.

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