Research progress of radiotherapy-based comprehensive therapy in primary hepatocellular carcinoma

Abstract

Abstract: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy, and most patients present with advanced liver cancer and a poor survival prognosis. With the development of new technologies and drug therapies, the value of radiotherapy, chemotherapy, targeted and immune drugs in HCC has been valued, especially for patients without surgical resection opportunities, and combination with hepatic artery chemoembolization is expected to become a new treatment option for HCC. For inoperable small liver cancer or early liver cancer, stereotactic radiation therapy has become one of the radical means. In addition, radiotherapy can promote the effect of immunotherapy by releasing tumor antigens, the two have a synergistic effect, in the inoperable late HCC radiotherapy combined with targeted, immunotherapy has achieved remarkable results in many clinical trials, and is safe and controllable. This paper mainly summarizes the latest research progress of radiotherapy combined drug therapy in HCC, and provides more combination treatment references and clinical research exploration directions for the current clinical treatment of primary liver cancer, especially advanced liver cancer.

Key words: Hepatocellular carcinoma, Radiotherapy, Targeted therapy, Immunotherapy

Yin Li, Guo Wenjie, Yuan Fangqin, Xu Qingyu, Yao Chengyun, He Xia. Research progress of radiotherapy-based comprehensive therapy in primary hepatocellular carcinoma[J]. Electronic Journal of Liver Tumor, 2023, 10(4): 60-67.

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