Meta-analysis of the effect of exercise intervention on the quality of life of liver transplant patients

Abstract

Abstract: Objective: To systematically evaluate the effect of exercise intervention on the quality of life of liver transplant (LT) patients.
Methods: A computer search was performed on databases such as CNKI, Wanfang Database, VIP, Sinomed, Cochrane Library, PubMed, Embase, and Web of Science. The search period was from the establishment of the database to September 2024. The literature that met the inclusion and exclusion criteria was analyzed using Revman5.4.1.
Results: Eight articles were finally included, and Meta analysis results showed that exercise intervention could improve the physical health quality of life of LT patients (WMD=12.15, 95%CI: 4.51-19.78, P=0.020), physiological functioning (WMD=18.42, 95%CI: 5.21-31.63, P=0.006), role physical (WMD=10.02, 95%CI: 0.34-19.71, P=0.040), and could reduce body pain (WMD=12.82, 95%CI: 0.23-25.41, P=0.050), still could improve general health (WMD=11.89, 95%CI: 3.21-20.57, P=0 .007), mental health quality of life (WMD=8.29, 95%CI : 2.77-13.80, P=0.003), vitality (WMD=10.14, 95%CI: 5.89-14.39, P<0.000 01), social functioning (WMD=5.50, 95%CI: 0.75-10.24, P=0.020); but there was no significant effect on role emotional (WMD=15.62, 95%CI: -0.64-31.88, P=0.060) and mental health (WMD=6.85, 95%CI: -5.63-19.32, P=0.280).
Conclusion: Exercise intervention can improve the physical health and some mental health quality of life scores of LT patients.

Key words: Liver transplantation, Exercise, Quality of life, Meta analysis

Zheng Yulin, Zhang Lili, Guo Huimin, Liu Xin, Xi Shuangmei, Wang Chaoqun, Gu Yanmei, Jing Xuemin. Meta-analysis of the effect of exercise intervention on the quality of life of liver transplant patients[J]. Electronic Journal of Liver Tumor, 2025, 12(3): 30-35.

References 24

[1]	中国医师协会器官移植医师分会,中华医学会器官移植学分会肝移植学组. 中国肝癌肝移植临床实践指南(2021版)[J/CD] . 实用器官移植电子杂志,2022,10(6):481-489.
[2]	DEVARBHAVI H, ASRANI S K, ARAB J P, et al.Global burden of liver disease: 2023 update[J] . J HePatol, 2023, 79(2): 516-537.
[3]	MATESANZ R, MAHILLO B, ALVAREZ M, et al.Global observatory and database on donation and transplantation: world overview on transplantation activities[J] . Transplant Proc, 2009, 41(6): 2297-2301.
[4]	LAI J C, SHUI A M, DUARTE-ROJO A, et al.Association of frailty with health-related quality of life in liver transplant recipients[J] . JAMA Surg, 2023, 158(2): 130-138.
[5]	GITTO S, GOLFIERI L, MANNELLI N, et al.Quality of life in liver transPlant reciPients during the corona virus disease 19 pandemic: a multicentre study[J] . Liver Int, 2022, 42(7): 1618-1628.
[6]	EASL clinical practice guidelines: liver transplantation[J] . J HePatol, 2016, 64(2): 433-485.
[7]	DE ARAÚJO M C, BEZERRA P C, DE SOUSA C M, et al. The effect of a comprehensive rehabilitation program on respiratory function and functional capacity on patients after 1 month to liver transplantation[J] . TransPlant Proc, 2023, 55(1): 178-183.
[8]	BURKHARDT J A, RAPPORT M.Quality of life and functional mobility after progressive resistance exercise in an adolescent with a liver transplant[J] . Pediatr Phys Ther, 2020, 32(4): E70-E75.
[9]	ALSHAHRANI A N, AL-KHLAIWI T M, MEO S A. Impact of pre- and post-therapeutic exercises in sarcopenia and pain in liver transplant patients[J] . Cureus, 2024, 16(7): e64360.
[10]	刘贵容,任宇基, 郑海清,等. 康复训练对肝移植术后患者肺功能和运动功能影响的初步研究[J] . 中国康复医学杂志,2023,38(3):313-318, 393.
[11]	HICKMAN I J, HANNIGAN A K, JOHNSTON H E, et al.Telehealth-delivered, cardioprotective diet and exercise program for liver transplant recipients: a randomized feasibility study[J] . TransPlant Direct, 2021, 7(3): e667.
[12]	KRASNOFF J B, VINTRO A Q, ASCHER N L, et al.A randomized trial of exercise and dietary counseling after liver transplantation[J] . Am J Transplant, 2006, 6(8): 1896-1905.
[13]	MANDEL D W.Comparison of targeted lower extremity strengthening and usual care progressive ambulation in subjects post-liver transplant: a randomized controlled trial[D] . Florida: University of Miami, 2009: 257.
[14]	MOYA-NÁJERA D, MOYA-HERRAIZ Á, COMPTE-TORRERO L, et al. Combined resistance and endurance training at a moderate-to-high intensity improves physical condition and quality of life in liver transplant patients[J] . Liver Transpl, 2017, 23(10): 1273-1281.
[15]	TOTTI V, TAME M, BURRA P, et al.Physical condition, glycemia, liver function, and quality of life in liver transplant recipients after a 12-month supervised exercise program[J] . Transplant Proc,2019, 51(9): 2952-2957.
[16]	周琛,张林颖,王宇. 体育锻炼对肝移植受体者健康相关生存质量的影响[J] . 中华现代护理杂志,2012,18(25):3001-3004.
[17]	RONGIES W, STEPNIEWSKA S, LEWANDOWSKA M, et al.Physical activity long-term after liver transplantation yields better quality of life[J] . Ann TransPlant, 2011, 16(3): 126-131.
[18]	YUKSEL ERGENE T, KARADIBAK D, DONMEZ R, et al.Effects of early resistance training after liver transplantation procedures: a randomized controlled pilot trial[J] . 2022, 33(10): 852-861.
[19]	KÖMÜRKARA S, CENGIZ Z. Effects of progressive relaxation exercises on vital signs and fatigue in liver transplant patients: a randomized controlled trial[J] . Clin Nurs Res, 2022, 31(3): 497-508.
[20]	MASCHERINI G, CORSI M, FALCONI E, et al.Unsupervised exercise intervention vs. adherence to a mediterranean diet alone: the role of bioelectrical impedance vector analysis and cardiovascular performance in liver-transplanted recipients[J] . Nutrients, 2024, 16(2): 190.
[21]	SERPER M, JONES L S, CLEMENT T, et al.A randomized, controlled, prehabilitation intervention to maximize early recovery (PRIMER) in liver transplantation[J] . Liver Transplantation, 2024, 30(1): 10-19.
[22]	SMITH P J, MERWIN R M.The role of exercise in management of mental health disorders: an integrative review[J] . Annu Rev Med, 2021, 72: 45-62.
[23]	诸凤芳,顾爱芳,李枫,等. 有氧运动干预对抑郁症患者抑郁情绪及社会功能的影响[J] . 神经疾病与精神卫生, 2018,18(5):312-316.
[24]	李含,徐耀峥,李林静,等. 肝移植患者术后真实生活体验质性研究的Meta整合[J] . 中华现代护理杂志, 2023,29(10):1302-1309.