Correlation analysis of the indocyanine green retention rate at 15 minutes and the prognosis of patients with primary liver cancer after liver resection surgery

Abstract

Abstract: Objective: To analyze the correlation between the indocyanine green retention rate at 15 minutes(ICG-R15) and the prognosis of liver cancer patients after liver resection surgery.
Method: The clinical data of 242 patients with hepatocellular carcinoma from Xuanwu Hospital of Capital Medical University from May 2024 to March 2025 were collected. Among them, 130 cases had an ICG-R15 value less than 10%, and 112 cases had an ICG-R15 value of 10% or higher. The correlation between different ICG-R15 and surgical prognosis indicators (operation duration, intraoperative blood loss, number of intraoperative drainage tubes, hospital stay, hospital expenses, 24-hour postoperative pain score, postoperative hospital stay, discharge activities of daily living [ADL] score, postoperative liver function, postoperative liver function Child-Pugh classification, postoperative model for end-stage liver disease [MELD] score) was compared.
Result: The single-factor analysis showed that there were statistically significant differences in the operation duration, intraoperative blood loss, postoperative hospital stay, discharge ADL score, postoperative liver function, postoperative liver function Child-Pugh classification, and postoperative MELD score between the two groups (all P<0.05). The multivariate logistic regression analysis revealed that the operation duration, postoperative hospital stay, postoperative liver function, postoperative liver function Child-Pugh classification, and postoperative MELD score were all correlated with the preoperative ICG-R15 level (P<0.05).
Conclusion: ICG-R15 has a predictive effect on the postoperative liver function of patients with primary liver cancer. Preoperative determination of ICG-R15 levels is of great significance for evaluating liver reserve function, predicting the occurrence of postoperative liver dysfunction, and optimizing surgical treatment plans.

Key words: Indocyanine green retention rate at 15 minutes, Primary liver cancer, Hepatectomy, Prognosis

Zhang Mingming, Yang Ning, Wang Haijiao, Wang Xinran. Correlation analysis of the indocyanine green retention rate at 15 minutes and the prognosis of patients with primary liver cancer after liver resection surgery[J]. Electronic Journal of Liver Tumor, 2025, 12(4): 14-19.

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