Electronic Journal of Liver Tumor ›› 2020, Vol. 7 ›› Issue (2): 21-27.

• Original article • Previous Articles     Next Articles

Clinicopathological charateristics analysis for 23 cases of hepatic angiomyolipoma

Li Zhuo1, Wang Liming2, Zhang Haifeng1, Zhang Hongtu1, Shi Susheng1, Lu Haizhen1,*   

  1. 1 Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;
    2 Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  • Received:2020-03-27 Online:2020-06-30 Published:2020-07-23

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Abstract: Objective: The aim of the study was to investigate the clinicopathologic characteristics, immunohistochemical results, diagnosis, differential diagnosis and prognosis of hepatic angiomyolipoma (HAML).Methods: The 23 surgically excisional cases of HAML were collected and systematically analyzed in Cancer Hospital, Chinese Academy of Medical Sciences from December 2010 to December 2019. The clinical and pathological characteristics, including gender, age distribution, former medical history, symptoms, tumor location, size, gross and microscopic morphological features and immunohistochemical results were reviewed in the study.Results: There were 5 males and 18 females, with a median age of 46.8 years (range 27~66 years). The results of serological examination showed 5 cases of HAML patients with the infection of Hepatitis B virus. The test results of AFP and CEA in 20 cases were within the normal range. Only 5 cases of the 23 HAML were correctly diagnosed before the operations, with the other 15 cases diagnosed as hepatic carcinoma, 2 cases as hepatic hemangioma and 1 case as hepatic adenoma. There were 18 cases 78.3% out of the 23 HAML cases with epithelial components in our study. The immunohistochemical results of 23 cases showed the positive percentage ratio of HMB45 as 100%, SMA as 95.7% and 0 for the epithelial markers respectively. Except for only one case with the recurrence with the history of former operation from another hospital, no recurrence or metastasis in the other 22 cases was observed in our study.Conclusions: HAML was a type of mesenchymal neoplasm. The combined application of HMB45 and SMA immunohistochemical examination was proved to be essential for the correct diagnosis of HAML. Although there was higher existence of epithelial components in HAML than in renal counterpart, the favorable prognosis was still observed depending on the completely surgical resection in this study. Thus we assume that the epithelial components in HAML would not change its clinical outcome.

Key words: Epithelioid, Angiomyolipoma, HMB45