Effects of stroke volume variation guided goal-directed fluid therapy on liver and renal function of patients after liver cancer surgery

Abstract

Abstract: Objective: To investigate the effect of stroke volume variation (SVV) guided goal-directed fluid therapy (GDFT) on liver and renal function of patients after liver cancer surgeries. Methods: Sixty patients undergoing liver cancer surgeries in cancer hospital of Chinese academy of medical sciences were randomly divided into a low SVV group (1<SVV≤5) and a high SVV group (5<SVV≤9). In both groups, doses of ringer lactate were infused slowly at a steady speed. If SVV was higher than the threshold (SVV>5 in the low SVV group and SVV>9 in the high SVV group), a dose of 250ml hydroxyethyl starch 130/0.4 was given within 15 minutes to observe the changes of SVV. If SVV is still higher than the threshold, such dose was repeatedly given until SVV readings fall below the threshold. Records of fluid intake and output during operation, as well as operation time are done and kept, besides AST, ALT, APTT, Cr, BUN and other liver and renal function indicators within 3 days post-surgery. Results: The amount of fluid input was significantly reduced in the high SVV group, and there was no statistical difference in postoperative liver and kidney function compared with the low SVV group. Conclusion: Goal-directed fluid therapy based on SVV guidance will facilitate intraoperative fluid input limitation and intraoperative fluid management in liver cancer surgery .

Key words: Goal-directed fluid therapy, Stroke volume variation, Liver cancer surgery, Liver and renal function

Liu Chao, Zou Liang, Zheng Hui. Effects of stroke volume variation guided goal-directed fluid therapy on liver and renal function of patients after liver cancer surgery[J]. Electronic Journal of Liver Tumor, 2020, 7(3): 12-16.

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