Abstract: Objective: To evaluate the prognostic value of glasgow prognostic score(GPS), prognostic nutritional index (PNI), model for end-stage liver disease(MELD) score and WPCBAL score in end-stage primary liver cancer(PLC) patients. Methods: Clinical data of 50 end-stage PLC patients discharged dead from the Cancer Hospital of the Chinese Academy of Medical Sciences between January 2010 to April 2020 were retrospectively analyzed. The general information and scores of four prognostic tools on last admission were collected. Differences of survival time among prognostic tools were compared by the log-rank test. Predictive values of various prognostic tools for 3-week mortality were evaluated by the receiver operating characteristic curve(ROC) analysis. Results: The median survival time was 9.5 days (95% CI: 6 ~15 days), and the 3-week mortality rate was 80.0%. Log-rank test showed that the survival time of MELD score≥ 15 group was shorter than MELD score < 15 group (7d vs. 16d, P = 0.002), and WPCBAL score≥ 5 group had a shorter survival time than WPCBAL score < 5 group (7d vs. 10d, P = 0.029). ROC analysis showed that the area under the ROC (AUC) of MELD score and WPCBAL score in predicting 3 week survival of patients with end-stage liver cancer were 0.7325 (95% CI: 0.5571~0.9079) and 0.6838 (95% CI: 0.5188~0.8487), respectively. Conclusion: MELD score and WPCBAL score are valuable in predicting the short-term survival status of end-stage PLC patients with low sensitivity.

Key words: Primary liver cancer, End-stage liver disease, Prognosis