Laparoscopic versus open liver resection for resectable multiple hepatocellular carcinomas beyond Milan criteria

Abstract

Abstract: Objective: To assess the safety and efficacy of laparoscopic versus open liver resection for patients with resectable multiple hepatocellular carcinomas (HCCs) beyond Milan criteria.
Methods: A total of 217 patients met the inclusion and exclusion criteria were enrolled in this study, and there were 75 patients in the laparoscopic liver resection group (LLR) and 142 patients in the open liver resection group (OLR). 1:1 propensity score matching (PSM) was performed to calculate short- and long-term outcomes between the two groups.
Results: 72 patients with well-balanced baselines were included into each group. LLR had longer operative time (median, 237.5 min vs. 210 min, P=0.024), less intraoperative blood loss (median, 200 ml vs. 350 ml, P=0.005), less complications (P=0.035), and equivalent survival outcomes (OS, P=0.827; RFS, P=0.694) when compared with OLR.
Conclusion: LLR could be effective for some selected patients with resectable multiple HCCs beyond Milan criteria, and it had superior perioperative outcomes and similar oncological outcomes when compared with OLR.

Key words: Laparoscope, Hepatectomy, Resectable multiple hepatocellular carcinoma, Perioperation, Prognosis

Peng Yufu, Liu Fei, Li Bo, Wei Yonggang. Laparoscopic versus open liver resection for resectable multiple hepatocellular carcinomas beyond Milan criteria[J]. Electronic Journal of Liver Tumor, 2021, 8(4): 13-16.

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