Research progress of autophagy in interventional therapy of primary hepatic carcinoma

Abstract

Abstract: Primary hepatic carcinoma is one of most common malignant tumors in China. Interventional therapy plays an important role in primary hepatic carcinoma, suitable for Ia-IIIb stage patients according to China liver cancer staging (CNLC). As a metabolic process unique to eukaryotic cells, autophagy is involved in metabolic diseases and malignant tumors, and plays an important role in the tumorigenesis of primary hepatic carcinoma, especially promoting the tolerance of tumor cells to interventional therapy, which makes the treatment ineffective. In this paper, we review the effects of common interventional treatments for primary hepatic carcinoma on autophagy in tumor cells. Ablation therapy, transvascular interventional therapy, and internal radiation therapy can promote levels of autophagy in tumor cells by cellular pathways such as hypoxia inducible factor-1α (HIF-1α)/B-cell lymphoma-2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3) pathway, phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR), resulting in treatment resistance. In vitro studies, the use of autophagy inhibitors has prevent therapeutic resistance from autophagy.

Key words: Autophagy, Primary hepatic carcinoma, Interventional therapy

Yu Chenxi, Yao Xuesong. Research progress of autophagy in interventional therapy of primary hepatic carcinoma[J]. Electronic Journal of Liver Tumor, 2023, 10(2): 33-36.

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