Electronic Journal of Liver Tumor ›› 2024, Vol. 11 ›› Issue (1): 25-29.

• Review • Previous Articles     Next Articles

Research progress of lenvatinib for hepatocellular carcinoma

Pei Xirui1, Li Xiaohang2,*   

  1. 1. First Clinical Department, First Hospital of China Medical University, Shenyang 110122, Liaoning, China;
    2. Department of Hepatobiliary Surgery, First Hospital of China Medical University, Shenyang 110001, Liaoning, China
  • Received:2023-02-16 Online:2024-03-31 Published:2024-05-08
  • Contact: *Li Xiaohang, E-mail: med328@163.com

Abstract: Hepatocellular carcinoma is a major challenge affecting global health and has been recognised as a leading cause of death both in China and the world. Due to its insidious, rapidly progressive and highly malignant nature, many patients with hepatocellular carcinoma have already lost their chance of surgery by the time they are diagnosed. Lenvatinib has the ability to inhibit the growth of both tumor cells and tumor angiogenesis, which results in a better effect on patients with unresectable hepatocellular carcinoma and significantly prolongs the overall survival of patients. Therefore, lenvatinib is considered as a first-line target drug for the treatment of unresectable hepatocellular carcinoma. This article presents a systematic review about the research progress of lenvatinib for hepatocellular carcinoma and future perspectives.

Key words: Hepatocellular carcinoma, Lenvatinib, Molecularly targeted therapy