Effect of hepatic R1 margin on intrahepatic recurrence of colorectal cancer liver metastases

Abstract

Abstract: Objective: The effect of R1 margin on liver resection for colorectal cancer liver metastasis (CRLM) has been controversial, and there is a lack of models for the effect of hepatic R1 margin on intrahepatic margin recurrence. This study aimed to construct a predictive model for intrahepatic margin recurrence in CRLM patients to understand whether there is an effect of R1 margin on intrahepatic margin recurrence.
Methods: The data of 123 CRLM patients undergoing surgical treatment in the General Surgery Department of Peking University Third Hospital from January 2009 to December 2020 were retrospectively analyzed, and the factors with independent predictive value for intrahepatic margin recurrence were established through binary Logistic regression analysis, and the predictive model was established.
Results: The whole cohort had 48 (39.0%) and 75 (61.0%) non-hepatic recurrence.73 (59.3%) of R0 resection and 50 (40.7%) of R1 resection. In the univariate regression analysis, the maximum diameter of metastases (OR=2.396, P=0.041), non-anatomical resection (OR=3.732, P=0.025), operation duration (OR=2.571, P=0.013), liver R1 margin (OR=2.907, P=0.005) were significantly associated with hepatic R. margin recurrence. After multivariate regression analysis, R1 margin was no longer statistically significant (OR=2.103, 95%CI: 0.94-4.65, P=4.70), while metastasis with maximum diameter >21 mm (OR=2.509, 95%CI: 1.02-6.17, P=0.045) and non-anatomical resection (OR=3.585, 95%CI: 1.06-12.15, P=0.040) had independent predictive value for intrahepatic margin recurrence.
Conclusions: The R1 margin in the model established in this study seemed to increase the risk of intrahepatic margin recurrence, but did not reach statistical significance. Independent risk factors affecting intrahepatic margin recurrence were the maximum diameter of hepatic metastases and non-anatomical resection.

Key words: Colorectal cancer liver metastasis, R1 resection margin, Intrahepatic resection margin recurrence

Ai Xiangnan, Wang Hangyan, Zhang Wenxuan, Jin Changguo, Wu Zhenyu, Xiu Dianrong. Effect of hepatic R1 margin on intrahepatic recurrence of colorectal cancer liver metastases[J]. Electronic Journal of Liver Tumor, 2024, 11(2): 37-42.

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