Clinical and pathological factors affecting the prognosis of patients with colorectal liver metastasis

Abstract

Abstract: Objective: To investigate the clinical and pathological factors affecting the prognosis of patients with colorectal liver metastases (CRLM) patients.
Method: Patients with synchronous CRLM who were admitted to Peking University Third Hospital from March 2014 to March 2016 were retrospectively analyzed. The relevant clinical data, pathology of primary tumor and liver metastases of each patient were collected, and the patients were followed up. Univariate analysis and Cox regression were used to analyze the independent prognostic factors of CRLM.
Result: A total of 97 patients with CRLM were included in this study, including 57 males and 40 females, with an average age of (61.2±11.8) years, 54 cases in the right colon and 43 cases in the left colon and rectum. Univariate analysis showed that preoperative carcinoembryonic antigen (CEA)>32 ng/ml, preoperative carbohydrate antigen19-9 (CA19-9)>20 U/ml, presence of cancer nodules, postoperative N stage, primary tumor located in the right hemicolon, the number of liver metastases>3, and poor differentiation of the primary tumor were non-independent risk factors affecting the 3-year overall survival of patients (all P<0.05). Cox regression model was used for multivariate analysis, the results showed that preoperative CEA level (hazard ratio [HR]=2.123, 95% confidence interval [95%CI]: 1.151-3.918), preoperative CA19-9 level (HR=2.022, 95%CI: 1.094-3.738), primary tumor location (HR=0.502, 95%CI: 0.265-0.951) and tumor differentiation (HR=0.519, 95%CI: 0.300-0.899) were independent risk factors for prognosis.
Conclusion: The primary tumor located in the right hemicolon, the primary tumor poorly differentiated, the preoperative CEA >32 ng/ml, and the preoperative CA19-9 >20 U/ml are independent risk factors affecting the prognosis of patients with CRLM.

Key words: Colorectal liver metastasis, Prognosis, Influence factors

Wang Peng, Du Jundong, Wang Hangyan, Xiu Dianrong. Clinical and pathological factors affecting the prognosis of patients with colorectal liver metastasis[J]. Electronic Journal of Liver Tumor, 2024, 11(2): 43-47.

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