Electronic Journal of Liver Tumor ›› 2024, Vol. 11 ›› Issue (2): 66-71.

• Original article • Previous Articles     Next Articles

The prognostic value of preoperative platelet to neutrophil ratio in colorectal cancer patients with resectable synchronous liver metastases

Zhang Jixin1, Wu Liang2, Wu Xueliang1,3,*, Wang Likun4, Ma Hongqing5, Han Lei1   

  1. 1. Department of General Surgery, First Affiliated Hospital of Hebei North University, Zhangjiakou 075000,Hebei, China;
    2. Operating Room, First Affiliated Hospital of Hebei North University, Zhangjiakou 075000,Hebei, China;
    3. Institute of Oncology, First Affiliated Hospital of Hebei North University, Zhangjiakou 075000,Hebei, China;
    4. Department of Ultrasound, First Affiliated Hospital of Hebei North University, Zhangjiakou 075000,Hebei, China;
    5. The Second Department of General Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China
  • Received:2023-04-01 Online:2024-06-30 Published:2024-09-05
  • Contact: *Wu Xueliang, E-mail: wxlwlk@163.com

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Abstract: Objective: To investigate the prognostic value of preoperative serum platelet to lymphocyte ratios (PLR) in colorectal cancer patients with synchronous liver metastases.
Methods: The 74 patients clinicopathological data of in colorectal cancer patients with synchronous liver metastases who underwent liver resection in First Affiliated Hospital of Hebei North University were collected retrospectively. The X-tile software was used to calculate the best cut-off value of PLR toward prognosis, and the patients were divided into low PLR group (n=31) and high PLR group (n=43) according to the aforementioned cut-off value. Differences in general clinicopathological data and prognosis of the two group patients were investigated.
Results: The best cut-off for PLR prognosis was 188, PLR≥188 was the high PLR group and PLR<188 was the low PLR group. Compared with patients in the low PLR group, the tumor stage of the high PLR group was later, the lymph node metastasis rate was higher, and the number of liver metastases was more (all P<0.05). The median survival time of patients in the high PLR group and the low PLR group were 33 months and 11 months (P=0.001), respectively. The Cox model multivariate analysis showed that pT staging (HR=2.199, 95%CI: 1.156-4.182, P=0.016), carcinoembryonic antigen ≥3.4 ng/ml (HR=1.834, 95%CI: 1.079-3.117, P=0.025), and PLR≥188 (HR=1.885, 95%CI: 1.022-3.477, P=0.042) were independent risk factors for the colorectal cancer patients with synchronous liver metastases. The prognostic prediction model was constructed according to the results of the survival analysis, and the validity curve and the receiver operation characteristic curve showed good model fit and accuracy.
Conclusions: Preoperative PLR is closely related to the poor prognosis of colorectal cancer patients with synchronous liver metastases. Patients with preoperative PLR≥188 have a worse prognosis. The survival prediction models is constructed based on PLR, T stage and carcinoembryonic antigen have high accuracy and can be used to guide clinical practice.

Key words: Colorectal cancer, Liver metastasis, Platelet-neutrophil ratio, Prognosis