Progress on liver transplantation in the treatment of liver metastases

Abstract

Abstract: Liver transplantation has become an acceptable and effective treatment for primary malignant liver tumors according to Milan criteria. In recent years, with the development of comprehensive treatment, the emergence of targeted drugs and immunotherapy, the long-term prognosis of liver transplantation for some liver metastases has been significantly improved. And a new era of “Transplant Oncology” has begun. This article reviews the current status of liver transplantation for patients with liver metastases.

Key words: Liver transplantation, Liver metastases, Surgery

Lyu Shaocheng, Lang Ren. Progress on liver transplantation in the treatment of liver metastases[J]. Electronic Journal of Liver Tumor, 2021, 8(3): 26-29.

References

[1] SANTOPAOLO F, LENCI I, MILANA M, et al.Liver transplantation for hepatocellular carcinoma: Where do we stand?[J]. World J Gastroenterol, 2019, 25(21): 2591-2602.
[2] LINGIAH VA, NIAZI M, OLIVO R, et al.Liver Transplantation Beyond Milan Criteria[J]. J Clin Transl Hepatol, 2020, 8(1): 69-75.
[3] AMER A, WILSON CH, MANAS DM.Liver transplantation for unresectable malignancies: Beyond hepatocellular carcinoma[J]. Eur J Surg Oncol, 2019, 45(12): 2268-2278.
[4] HABERAL REYHAN N.Liver Transplant for Nonhepatocellular Carcinoma Malignancy[J]. Exp Clin Transplant, 2017, 15(Suppl 2): 69-73.
[5] http://www.eltr.org/Specific-results-by-disease.html
[6] HIBI T, ITANO O, SHINODA M, et al.Liver transplantation for hepatobiliary malignancies: a new era of "Transplant Oncology" has begun[J]. Surg Today, 2017, 47(4): 403-415.
[7] 郑虹. 新概念:移植肿瘤学——肝移植治疗难治性非HCC肝肿瘤[J]. 实用器官移植电子杂志,2019,7(1):63.
[8] HIBI T, SAPISOCHIN G.What is transplant oncology?[J]. Surgery, 2019, 165(2): 281-285.
[9] SAPISOCHIN G, JAVLE M, LERUT J, et al.Liver Transplantation for Cholangiocarcinoma and Mixed Hepatocellular Cholangiocarcinoma: Working Group Report From the ILTS Transplant Oncology Consensus Conference[J]. Transplantation, 2020, 104(6): 1125-1130.
[10] HIBI T, RELA M, EASON JD, et al.Liver Transplantation for Colorectal and Neuroendocrine Liver Metastases and Hepatoblastoma. Working Group Report From the ILTS Transplant Oncology Consensus Conference[J]. Transplantation, 2020, 104(6): 1131-1135.
[11] MEHTA N, BHANGUI P, YAO FY, et al.Liver Transplantation for Hepatocellular Carcinoma. Working Group Report from the ILTS Transplant Oncology Consensus Conference[J]. Transplantation, 2020, 104(6): 1136-1142.
[12] BERENGUER M, BURRA P, GHOBRIAL M, et al.Posttransplant Management of Recipients Undergoing Liver Transplantation for Hepatocellular Carcinoma. Working Group Report From the ILTS Transplant Oncology Consensus Conference[J]. Transplantation, 2020, 104(6): 1143-1149.
[13] 刘丹希,孙备. 胰腺神经内分泌肿瘤外科治疗策略[J]. 中华内分泌外科杂志,2020,14(3):177-180.
[14] 任思谦,陈晴,原春辉.胰腺神经内分泌肿瘤合并肝转移的多学科治疗策略[J]. 中华外科杂志,2020,58(7):499-504.
[15] PAVEL M, BAUDIN E, COUVELARD A, et al.ENETS Consensus Guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms of foregut, midgut, hindgut, and unknown primary[J]. Neuroendocrinology, 2012, 95(2): 157-176.
[16] LE TREUT YP, DELPERO JR, DOUSSET B, et al.Results of liver transplantation in the treatment of metastatic neuroendocrine tumors. A 31-case French multicentric report[J]. Ann Surg, 1997, 225(4): 355-364.
[17] LE TREUT YP, GREGOIRE E, BELGHITI J, et al.Predictors of long-term survival after liver transplantation for metastatic endocrine tumors: an 85-case French multicentric report[J]. Am J Transplant, 2008, 8(6): 1205-1213.
[18] LEHNERT T.Liver transplantation for metastatic neuroendocrine carcinoma: an analysis of 103 patients[J]. Transplantation, 1998, 66(10): 1307-1312.
[19] COPPA J, PULVIRENTI A, SCHIAVO M, et al.Resection versus transplantation for liver metastases from neuroendocrine tumors[J]. Transplant Proc, 2001, 33(1-2): 1537-1539.
[20] MAZZAFERRO V, PULVIRENTI A, COPPA J.Neuroendocrine tumors metastatic to the liver: how to select patients for liver transplantation?[J]. J Hepatol, 2007, 47(4): 460-466.
[21] NGUYEN NT, HARRING TR, GOSS JA, et al.Neuroendocrine Liver Metastases and Orthotopic Liver Transplantation: The US Experience[J]. Int J Hepatol, 2011, 2011: 742890.
[22] LE TREUT YP, GREGOIRE E, KLEMPNAUER J, et al.Liver transplantation for neuroendocrine tumors in Europe-results and trends in patient selection: a 213-case European liver transplant registry study[J]. Ann Surg, 2013, 257(5): 807-815.
[23] MAZZAFERRO V, SPOSITO C, COPPA J, et al.The Long-Term Benefit of Liver Transplantation for Hepatic Metastases From Neuroendocrine Tumors[J]. Am J Transplant, 2016, 16(10): 2892-2902.
[24] SHIMATA K, SUGAWARA Y, HIBI T.Liver transplantation for unresectable pancreatic neuroendocrine tumors with liver metastases in an era of transplant oncology[J]. Gland Surg, 2018, 7(1): 42-46.
[25] PAVEL M, O'TOOLE D, COSTA F, et al. ENETS Consensus Guidelines Update for the Management of Distant Metastatic Disease of Intestinal, Pancreatic, Bronchial Neuroendocrine Neoplasms (NEN) and NEN of Unknown Primary Site[J]. Neuroendocrinology, 2016, 103(2): 172-185.
[26] 中国临床肿瘤学会神经内分泌肿瘤专家委员会. 中国胃肠胰神经内分泌肿瘤专家共识(2016年版)[J]. 临床肿瘤学杂志, 2016,21(10):927-946.
[27] BRAY F, FERLAY J, SOERJOMATARAM I, et al.Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6): 394-424.
[28] 毕新宇,蔡建强. 结直肠癌肝转移外科治疗相关问题的思考[J]. 中华肝胆外科杂志,2020,26(10):721-724.
[29] 赵之明,谭向龙,刘荣. 结直肠癌同步肝转移的治疗现状及研究进展[J]. 中华胃肠外科杂志,2020,23(6):619-622.
[30] PENN I.Hepatic transplantation for primary and metastatic cancers of the liver[J]. Surgery, 1991, 110(4): 726-735.
[31] MUHLBACHER F, HUK I, STEININGER R, et al.Is orthotopic liver transplantation a feasible treatment for secondary cancer of the liver?[J]. Transplant Proc, 1991, 23(1 Pt 2): 1567-1568.
[32] HAGNESS M, FOSS A, LINE PD, et al.Liver transplantation for nonresectable liver metastases from colorectal cancer[J]. Ann Surg, 2013, 257(5): 800-806.
[33] HAGNESS M, FOSS A, EGGE TS, et al.Patterns of recurrence after liver transplantation for nonresectable liver metastases from colorectal cancer[J]. Ann Surg Oncol, 2014, 21(4): 1323-1329.
[34] TOSO C, PINTO MARQUES H, AADRES A, et al.Liver transplantation for colorectal liver metastasis: Survival without recurrence can be achieved[J]. Liver Transpl, 2017, 23(8): 1073-1076.
[35] DUELAND S, SYVERSVEEN T, SOLHEIM JM, et al.Survival Following Liver Transplantation for Patients With Nonresectable Liver-only Colorectal Metastases[J]. Ann Surg, 2020, 271(2): 212-218.
[36] DUELAND S, GRUT H, SYVERSVEEN T, et al.Selection criteria related to long-term survival following liver transplantation for colorectal liver metastasis[J]. Am J Transplant, 2020, 20(2): 530-537.
[37] WILSON JM, CARDER P, DOWNEY S, et al.Treatment of metastatic breast cancer with liver transplantation[J]. Breast J, 2003, 9(2): 126-128.
[38] 宋新明,詹文华,汪建平,等. 胃肠肿瘤根治联合肝移植术治疗晚期胃肠肿瘤并肝脏广泛转移[J]. 中华胃肠外科杂志,2005,8(5):419-421.
[39] SUMIDA W, KANEKO K, TAINAKA T, et al.Liver transplantation for multiple liver metastases from solid pseudopapillary tumor of the pancreas[J]. J Pediatr Surg, 2007, 42(12): e27-e31.
[40] LAGIEWSKA B, PACHOLCZYK M, LISIK W, et al.Liver transplantation for nonresectable metastatic solid pseudopapillary pancreatic cancer[J]. Ann Transplant, 2013, 18: 651-653.
[41] WOJCIAK M, GOZDOWSKA J, PACHOLCZYK M, et al.Liver Transplantation for a Metastatic Pancreatic Solid-Pseudopapillary Tumor (Frantz Tumor): A Case Report[J]. Ann Transplant, 2018, 23: 520-523.
[42] ZHAO J, YAN LN, LI B.Adult-to-adult living donor liver transplantation for malignant metastatic melanoma to the liver[J]. Hepatobiliary Pancreat Dis Int, 2010, 9(3): 329-332.
[43] SERRALTA AS, SANJUAN FR, MOYA AH, et al.Combined liver transplantation plus imatinib for unresectable metastases of gastrointestinal stromal tumours[J]. Eur J Gastroenterol Hepatol, 2004, 16(11): 1237-1239.
[44] CAMERON S, RAMADORI G, FUZESI L, et al.Successful liver transplantation in two cases of metastatic gastrointestinal stromal tumors[J]. Transplantation, 2005, 80(2): 283-284.
[45] HUSTED TL, NEFF G, THOMAS MJ, et al.Liver transplantation for primary or metastatic sarcoma to the liver[J]. Am J Transplant, 2006, 6(2): 392-397.
[46] 袁航,滕飞,丁国善. 转移性肝癌肝移植的临床研究进展[J]. 实用器官移植电子杂志,2019,7(1):31-34.
[47] ABREU P, GORGEN A, OLDANI G, et al.Recent advances in liver transplantation for cancer: The future of transplant oncology[J]. JHEP Rep, 2019, 1(5): 377-391.