Immune checkpoint inhibitors in liver transplantation patients with hepatocellular carcinoma

Abstract

Abstract: Hepatocellular carcinoma (HCC) is one of the most malignant solid tumors. Liver transplantation is currently the most effective treatment for HCC. However, most of the patients have exceeded the transplantation standards when they are first diagnosed. Besides, the recurrence of tumors after surgery also seriously affects the long-term survival of patients who have accepted transplantation. Immunotherapy is a new treatment of solid tumors. Some HCC patients who received immunotherapy achieved tumor downgrading or elimination in previous reports. In this review, we mainly discuss current research progress of immune checkpoint inhibitors in the downstage or bridging therapy before liver transplantation, as well as in the treatment of recurrence cancer after liver transplantation.

Key words: Hepatocellular carcinoma, Liver transplantation, Immunotherapy

Xiong Jun, Wan Chidan. Immune checkpoint inhibitors in liver transplantation patients with hepatocellular carcinoma[J]. Electronic Journal of Liver Tumor, 2021, 8(3): 30-34.

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