The progress of radiotherapy in hepatocellular carcinoma with portal vein tumor thrombus

Abstract

Abstract: With a poor prognosis, hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) progresses rapidly and is life-threatening. Currently, the treatment options for HCC with PVTT mainly include transcatheter arterial intervention, radiotherapy, targeted therapy, immunotherapy, surgery, etc., but there is still no standard treatment strategy. Intensity-modulated radiotherapy can significantly raise the prescribed dose with the minimum dose delivery to the remaining liver, ensuring the safety of radiotherapy for HCC. Previous clinical studies have confirmed the safety and efficacy of radiotherapy for HCC with PVTT. With the deepening of the multidisciplinary treatment concept, radiotherapy combined with other treatments for HCC with PVTT has been continuously explored. Focusing on radiotherapy for HCC with PVTT, this review mainly discusses the progress of multidisciplinary combined therapy including radiotherapy, surgery, interventional therapy, targeted therapy, and immunotherapy.

Key words: Hepatocellular carcinoma, Portal vein tumor thrombus, Radiotherapy

Xin Lingxia, Xu Xin, Zhai Yirui, Deng Min, Chen Bo. The progress of radiotherapy in hepatocellular carcinoma with portal vein tumor thrombus[J]. Electronic Journal of Liver Tumor, 2023, 10(3): 76-82.

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