Abstract: Liver cancer ranks fifth in the incidence of malignant tumors and second in the causes of cancer-related death in China. Most of the patients have already developed to the middle and late stages when characteristic symptoms appear, have missed the best time for surgery, so palliative therapy plays a central role in the treatment of hepatocellular carcinoma. Locoregional treatment is one of the main therapeutic options for patients with unresectable hepatocellular carcinoma (uHCC), and immunotherapy and targeted systemic therapy have also made substantial progress in recent years, but the effect of interventional therapy alone or monotherapy is limited. Several combination therapy options have been actively explored in clinical studies, with encouraging efficacy and brought hope for the treatment of uHCC patients. Among them,the new combination of locoregional combined with systemic therapy is expected to be a potential therapeutic modality for intermediate and advanced hepatocellular carcinoma. This review provides an overview of the current status of research on locoregional combined with systemic therapy, aim to provide more treatment strategies for uHCC patients.

Key words: Locoregional therapies, Systemic therapies, Hepatocellular carcinoma, Research progress