Research progress on hand-foot skin reaction in targeted therapy for hepatocellular carcinoma

Abstract

Abstract: Targeted drugs, as an important means in the treatment of liver cancer, have significantly improved the overall survival rate of liver cancer patients. However, some side effects inevitably occur during treatment. Hand-foot skin reaction is one of the common adverse reactions, which not only affects the patient's quality of life, but may also force the patient to reduce the dosage of the drug or interrupt treatment. , thus affecting the therapeutic effect. This article comprehensively analyzes the current research status of hand-foot skin reactions related to targeted drugs at home and abroad, discusses its pathogenesis, clinical manifestations, and grading standards, and compares the differences in chemotherapy-related hand-foot syndrome. In addition, this article also focuses on the prevention and care strategies, health education, traditional Chinese and Western medicine treatments for hand-foot skin reactions, etc, aiming to reduce patients' symptoms, improve their quality of life, and improve their treatment compliance. At the same time, the existing problems and future development trends of hand-foot skin reactions in liver cancer targeted therapy are summarized, with a view to providing a comprehensive reference basis for clinicians and nursing workers, and for the prevention and management of hand-foot skin reactions related to liver cancer targeted drug treatment.

Key words: Hepatocellular carcinoma, Targeted therapy, Hand-foot skin reactions, Intervention measure

Ning Yanting, Xia Juan, Wu Shu, Zhang Qi, Li Xiaoqing, Che Xu, Zhan Zhengyin. Research progress on hand-foot skin reaction in targeted therapy for hepatocellular carcinoma[J]. Electronic Journal of Liver Tumor, 2024, 11(4): 54-59.

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