肝癌电子杂志 ›› 2025, Vol. 12 ›› Issue (2): 1-7.

• 专家述评 •    下一篇

放射性肝病三级预防专家指导意见

吴志峰, 曾昭冲*   

  1. 复旦大学附属中山医院放射治疗科,上海 200032
  • 收稿日期:2024-07-29 发布日期:2025-07-29
  • 通讯作者: *曾昭冲,E-mail:zeng.zhaochong@zs-hospital.sh.cn

Expert guidance on three-level prevention of radiation-induced liver diseases

Wu Zhifeng, Zeng Zhaochong*   

  1. Department of Radiotherapy, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China
  • Received:2024-07-29 Published:2025-07-29
  • Contact: *Zeng Zhaochong, E-mail: zeng.zhaochong@zs-hospital.sh.cn

摘要: 随着肝癌等腹部肿瘤放射治疗疗效的提高,放射诱导的放射性肝病(radiation induced liver diseases, RILD)的临床矛盾日益突出。作为腹部肿瘤放射治疗的剂量限制性并发症之一,RILD目前尚无相关临床三级预防的共识。本文在阐明RILD发病机制的基础上,分三级归纳总结了RILD 防治的影响因素与相应防治措施,并给出专家指导意见,旨在让临床医师熟悉、掌握防治腹部肿瘤放射治疗过程中的潜在致命性RILD。

关键词: 肝癌, 放射治疗, 放射性肝病, 临床三级预防, 腹部肿瘤

Abstract: With the improvement of the efficacy of radiotherapy (RT) for abdominal tumors such as liver cancer, the clinical contradiction between the efficacy of RT and the occurrence of radiation-induced liver diseases (RILD) has become increasingly prominent. As one of the dose-limiting complications of abdominal tumor RT, RILD currently lacks a consensus on the clinical three-level prevention. On the basis of elucidating the pathogenesis of RILD, this article summarizes the influencing factors and corresponding prevention and treatment measures of RILD prevention and treatment in three levels, and provides expert guidance, summarizes the influencing factors and corresponding measures for RILD prevention and control at three levels, with the aim of enabling clinicians to be familiar with and master the potential fatal RILD during the RT process for abdominal tumors.

Key words: Liver cancer, Radiotherapy, Radiation induced liver diseases, Clinical three-level prevention, Abdominal tumor