吲哚菁绿15 min滞留率与原发性肝癌患者肝切除术预后的相关性分析

摘要/Abstract

摘要： 目的：分析吲哚菁绿15 min滞留率（indocyanine green retention rate at 15 minutes, ICG-R15）与原发性肝癌患者肝切除术预后的相关性。
方法：回顾性分析首都医科大学宣武医院2024年5月至2025年3月242例肝细胞癌患者的临床资料。其中,ICG-R15<10%组130例,ICG-R15≥10%组112例。分析术前ICG-R15水平与手术预后指标[手术时间、术中出血量、术中留置引流管数量、住院时间、住院费用、术后24 h疼痛评分、术后住院时间、出院日常生活能力（activities of daily living, ADL）评分、术后肝功能、术后肝功能Child-Pugh分级、术后终末期肝病模型（model for end-stage liver disease, MELD）评分]的相关性。
结果：两组患者手术时间、术中出血量、术后住院时间、出院ADL评分及术后肝功能、术后肝功能Child-Pugh分级、术后MELD评分差异均有统计学意义（P均<0.05）。多因素logistic回归分析结果显示,手术时间、术后住院时间、术后肝功能、术后肝功能Child-Pugh分级、术后MELD评分与术前ICG-R15水平相关（P均<0.05）。
结论：术前ICG-R15与原发性肝癌患者术后肝功能密切相关。术前测定ICG-R15对于评估肝脏储备功能、预测术后肝功能不全的发生及优化手术治疗方案具有重要意义。

关键词: 吲哚菁绿15分钟滞留率, 原发性肝癌, 肝切除术, 预后

Abstract: Objective: To analyze the correlation between the indocyanine green retention rate at 15 minutes(ICG-R15) and the prognosis of liver cancer patients after liver resection surgery.
Method: The clinical data of 242 patients with hepatocellular carcinoma from Xuanwu Hospital of Capital Medical University from May 2024 to March 2025 were collected. Among them, 130 cases had an ICG-R15 value less than 10%, and 112 cases had an ICG-R15 value of 10% or higher. The correlation between different ICG-R15 and surgical prognosis indicators (operation duration, intraoperative blood loss, number of intraoperative drainage tubes, hospital stay, hospital expenses, 24-hour postoperative pain score, postoperative hospital stay, discharge activities of daily living [ADL] score, postoperative liver function, postoperative liver function Child-Pugh classification, postoperative model for end-stage liver disease [MELD] score) was compared.
Result: The single-factor analysis showed that there were statistically significant differences in the operation duration, intraoperative blood loss, postoperative hospital stay, discharge ADL score, postoperative liver function, postoperative liver function Child-Pugh classification, and postoperative MELD score between the two groups (all P<0.05). The multivariate logistic regression analysis revealed that the operation duration, postoperative hospital stay, postoperative liver function, postoperative liver function Child-Pugh classification, and postoperative MELD score were all correlated with the preoperative ICG-R15 level (P<0.05).
Conclusion: ICG-R15 has a predictive effect on the postoperative liver function of patients with primary liver cancer. Preoperative determination of ICG-R15 levels is of great significance for evaluating liver reserve function, predicting the occurrence of postoperative liver dysfunction, and optimizing surgical treatment plans.

Key words: Indocyanine green retention rate at 15 minutes, Primary liver cancer, Hepatectomy, Prognosis

张明名, 杨宁, 王海娇, 王欣然. 吲哚菁绿15 min滞留率与原发性肝癌患者肝切除术预后的相关性分析[J]. 肝癌电子杂志, 2025, 12(4): 14-19.

Zhang Mingming, Yang Ning, Wang Haijiao, Wang Xinran. Correlation analysis of the indocyanine green retention rate at 15 minutes and the prognosis of patients with primary liver cancer after liver resection surgery[J]. Electronic Journal of Liver Tumor, 2025, 12(4): 14-19.

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