肝细胞癌自发性破裂出血治疗的研究进展

肝癌电子杂志 ›› 2022, Vol. 9 ›› Issue (2): 23-27.

肝细胞癌自发性破裂出血治疗的研究进展

黄小准¹, 王春玲¹, 刘宜兵², 李晓青¹, 黄璋侃¹, 徐林¹, 倪勇³, 车旭^1,4, 毕新宇^5,*

1.国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院深圳医院肝胆外科,广东深圳 518116;
2.深圳市龙岗区中心医院普外科,广东深圳 518116;
3.深圳市第二人民医院深圳大学第一附属医院肝胆胰外科,广东深圳 518035;
4.国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院胰胃外科,北京 100021;
5.国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院肝胆外科,北京 100021

收稿日期:2022-02-07 发布日期:2022-10-26
通讯作者: ^*毕新宇,E-mail：beexy1971@163.com
作者简介:黄小准,国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院深圳医院, 肝胆外科
基金资助:
深圳市“医疗卫生三名工程”项目（SZSM202011010）; 深圳市高水平医院建设专项基金

Research progress of spontaneous ruptured hepatocellular carcinoma

Huang Xiaozhun¹, Wang Chunling¹, Liu Yibin², Li Xiaoqing¹, Huang Zhangkan¹, Xu Lin¹, Ni Yong³, Che Xu^1,4, Bi Xinyu^5,*

1. Department of Hepatobiliary Surgery, National Cancer Center/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, Guangdong, China;
2. Department of General Surgery, Longgang District Central Hospital of Shenzhen, Shenzhen 518116, Guangdong, China;
3. Department of Hepatopancreatobiliary Surgery, Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong, China;
4. Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;
5. Department of Hepatobiliary Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

Received:2022-02-07 Published:2022-10-26

摘要/Abstract

摘要： 肝细胞癌自发性破裂出血发病急,进展迅速,发病机制不明确,且患者肝功能背景复杂,个体之间异质性较大,不同的处理方式所取得的生存获益也不一致,对临床决策的选择造成了很大的困扰,因此寻找一些指标或模型来预测肝细胞癌自发性破裂患者的治疗预期意义重大。本文基于现有的临床证据,从肝细胞癌自发性破裂的机制阐述了高破裂倾向型肝细胞癌的手术时机,对肝细胞癌自发性破裂后不同处理方式所取得的近远期生存情况和多个模型对肝细胞癌治疗方式的预测效果,以及肝细胞自发性破裂幸存者的后续治疗策略进行综述。

关键词: 肝细胞癌, 自发性破裂, 肝癌切除术, 生存, 预测模型

Abstract: Spontaneously ruptured hepatocellular carcinoma (rHCC) with hemorrhage is characterized by rapid onset and progression, the pathogenesis is not clear, and liver background in rHCC patients was complicated. There is large heterogeneity between different ways of handling the survival benefit obtained, the choice of clinical decision caused great distress, so looking for some indicators or model to predict the treatment of patients with rHCC forecast is of great significance. This article is based on the existing clinical evidence, this article will review the research progress of rHCC with hemorrhage: From the rupture mechanism of hepatocellular carcinoma (HCC) are expounded of high burst tendency HCC of the operation time. Different treatments of short- and long-term survival benefit with multiple model prediction effect for the treatment of rHCC. Finally we explored the treatment of rHCC survivors.

Key words: Hepatocellular carcinoma, Spontaneously ruptured, Hepatectomy, Survival, Prediction model

黄小准, 王春玲, 刘宜兵, 李晓青, 黄璋侃, 徐林, 倪勇, 车旭, 毕新宇. 肝细胞癌自发性破裂出血治疗的研究进展[J]. 肝癌电子杂志, 2022, 9(2): 23-27.

Huang Xiaozhun, Wang Chunling, Liu Yibin, Li Xiaoqing, Huang Zhangkan, Xu Lin, Ni Yong, Che Xu, Bi Xinyu. Research progress of spontaneous ruptured hepatocellular carcinoma[J]. Electronic Journal of Liver Tumor, 2022, 9(2): 23-27.

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