结直肠癌肝转移切缘研究进展

摘要/Abstract

摘要： 肝转移瘤切缘是指从肿瘤边缘到肝脏切面的距离。肝脏是结直肠癌远处转移的主要靶器官,切缘问题既要遵循肝脏外科的基本原则,又要考虑结直肠癌肝转移特有的生物学特性,手术切缘是外科治疗中的焦点与难点问题。R0切除的定义经历了由切缘>1 cm到>1 mm的转变, 随着研究的深入,肿瘤R1切除逐渐被提出并在特定条件下接受。肿瘤高负荷、RAS基因突变、肿瘤病理及血管关系等与较高的R1切除率相关。本文拟就结直肠癌肝转移切缘研究进行回顾分析。

关键词: 结直肠癌, 肝转移, 切缘

Abstract: The resection margin of liver metastases refers to the distance from the tumor edge to the liver section. The liver is the main target organ for distant metastasis of colorectal cancer. The issue of resection margin should not only follow the basic principles of liver surgery, but also consider the unique biological characteristics of colorectal liver metastases. Surgical resection margin is the focus and difficulty in surgical treatment. The definition of R0 resection has undergone a shift from a margin greater than 1 cm to greater than 1 mm. With further research, tumor R1 resection has gradually been proposed and accepted under specific conditions. High tumor burden, RAS gene mutations, tumor pathology, and vascular relationships are associated with higher R1 resection rates. This article intends to review and analyze the study of surgical margins for liver metastases in colorectal cancer.

Key words: Colorectal cancer, Liver metastasis, Surgical margin

韩继祥, 赵建军, 王京涛. 结直肠癌肝转移切缘研究进展[J]. 肝癌电子杂志, 2025, 12(2): 26-29.

Han Jixiang, Zhao Jianjun, Wang Jingtao. Research progress on resection margin of liver metastasis in colorectal cancer[J]. Electronic Journal of Liver Tumor, 2025, 12(2): 26-29.

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