[1] PATEL T.Cholangiocarcinoma-controversies and challenges[J]. Nat Rev Gastroenterol Hepatol, 2011, 8(4):189-200. [2] CHOW PKH, GANDHI M, TAN SB, et al.SIRveNIB: selective internal radiation therapy versus sorafenib in Asia-Pacific patients with hepatocellular carcinoma[J]. J Clin Oncol, 2018, 36(19):1913-1921. [3] VALLE JW, WASAN H, JOHNSON P, et al.Gemcitabine alone or in combination with cisplatin in patients with advanced or metastatic cholangiocarcinomas or other biliary tract tumors: a multicentre randomised phase II study-the UK ABC-01 study[J]. Br J Cancer, 2009, 101(4):621-627. [4] LLOVET JM, RICCI S, MAZZAFERRO V, et al.Sorafenib in advanced hepatocellular carcinoma[J]. N Engl J Med, 2008, 359(4):378-390. [5] ESO Y, MARUSAWA H.Novel approaches for molecular targeted therapy against hepatocellular carcinoma[J]. Hepatol Res, 2018, 48(8):597-607. [6] COLLINS FS, GREEN ED, GUTTMACHER AE, et al.A vision for the future of genomics research[J]. Nature, 2003, 422(6934):835-847. [7] BRAY F, FERLAY J, SOERJOMATARAM I, et al.Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6):394-424. [8] VILLANUEVA A.Hepatocellular Carcinoma[J]. N Engl J Med, 2019, 380(15):1450-1462. [9] TORRE LA, BRAY F, SIEGEL RL, et al.Global cancer statistics, 2012[J]. CA Cancer J Clin, 2015, 65(2):87-108. [10] SIEGEL RL, MILLER KD, JEMAL A.Cancer statistics, 2017[J]. CA Cancer J Clin, 2017, 67(1):7-30. [11] SIEGEL RL, MILLER KD, JEMAL A. Cancer Statistics, 2018[J]. CA Cancer J Clin, 2018, 68(1):7-30. [12] LIU M, JIANG LX, GUAN XY.The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update[J]. Protein Cell, 2014, 5(9):673-691. [13] POGRIBNY IP, RUSYN I.Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma[J]. Cancer Lett, 2014, 342(2):223-230. [14] ALLY A, BALASUNDARAM M, CARLSEN R, et al.Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma[J]. Cell, 2017, 169(7):1327-1341. [15] SCHULZE K, IMBEAUD S, LETOUZE E, et al.Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets[J]. Nat Genet, 2015, 47(5):505-511. [16] TOTOKI Y, TATSUNO K, COVIINGTON KR, et al.Trans-ancestry mutational landscape of hepatocellular carcinoma genomes[J]. Nat Genet, 2014, 46(12):1267-1273. [17] HO DW, Kai AK, Ng IO.TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma[J]. Front Med, 2015, 9(3):322-330. [18] PENG T, LI ZH, LI DJ, et al.MACC1 promotes angiogenesis in cholang-iocarcinoma by upregulating VEGFA[J]. Onco Targets Ther, 2019, 12:1893-1903. [19] HOSHIDA Y, VILLANUEVA A, KOBAYASHI M, et al.Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma[J]. N Engl J Med, 2008, 359(19):1995-2004. [20] HOSHIDA Y, VILLANUEVA A, SANGIOVANNI A, et al.Prognostic gene expression signature for patients with hepatitis C-related early-stage cirrhosis[J]. Gastroenterology, 2013, 144(5):1024-1030. [21] KING LY, CANASTO-CHIBUQUE C, JOHNSON KB, et al.A genomic and clinical prognostic index for hepatitis C-related early-stage cirrhosis that predicts clinical deterioration[J]. Gut, 2015, 64(8):1296-1302. [22] 王晓云, 李林峰, 郭佺, 等. 肝胆肿瘤疾病智能化诊疗模式的发展及启示[J].临床肝胆病杂志, 2019, 35(10):2360-2364. [23] JIA XD, LU SS, ZENG Z, et al.Characterization of Gut Microbiota, Bile Acid Metabolism, and Cytokines in Intrahepatic Cholangiocarcino-ma[J]. Hepatology, 2020, 71(3):893-906. [24] XUE RD, CHEN L, ZHANG C, et al.Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes[J]. Cancer Cell, 2019, 35(6):932-947. [25] COLLINS FS, VARMUS H.A new initiative on precision medicine[J]. N Engl J Med, 2015, 372(9):793-795. [26] REARDON S.Precision-medicine plan raises hopes[J]. Nature, 2015, 517(7536):540. [27] MA LC, HERNANDEZ MO, ZHAO YM, et al.Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer[J]. Cancer Cell, 2019, 36(4):418-430. [28] GAO Q, ZHU HW, DONG LQ, et al.Integrated Proteogenomic Characteriza-tion of HBV-Related Hepatocellular Carcinoma[J]. Cell, 2019, 179(5):1240. [29] WANG C, VEGNA S, JIN HJ, et.al. Inducing and exploiting vulnerabilities for the treatment of liver cancer[J]. Nature, 2019, 574(7777):268-272. [30] HARADA K, BABA Y, ISHIMOTO T, et al.LINE-1 methylation level and patient prognosis in a database of 208 hepatocellular carcinoma[J]. Ann Surg Oncol, 2015, 22(4):1280-1287. [31] 陈谦, 仇小强. 基于大数据的肝癌血管侵袭标志物分析[J]. 中华流行病学杂志, 2017, 38(4):522-527. |