Electronic Journal of Liver Tumor ›› 2021, Vol. 8 ›› Issue (2): 43-46.

• Review • Previous Articles     Next Articles

Progress in diagnosis and treatment of combined hepatocellular cholangiocarcinoma

Huang Zhangkan1, Huang Xiaozhun1, Xu Lin1, Zhang Renjie1, Che Xu1,2, Sun Yongkun3,*   

  1. 1. Department of Hepatobiliary Surgery,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital &Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen 518116, Guangdong, China;
    2. Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021,China;
    3. Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021,China
  • Received:2021-02-09 Published:2021-07-16

Abstract: Combined hepatocellular-cholangiocarcinoma is a rare primary liver cancer, which contains a mixture of hepatocytes and cholangiocytes. Because of the diversity of histology and phenotype, it is difficult to diagnose and treat. With the development of biochemical methods and cancer stem cell theory, the special pathological classification, tumor biology and clinical manifestations of Combined hepatocellular-cholangiocarcinoma have been more and more recognized. The thesis summarizes the recent progress in combined hepatocellular-cholangiocarcinoma from the perspective of Pathology, diagnosis, and treatment.

Key words: Combined hepatocellular-cholangiocarcinoma, Liver neoplasms, Pathology, Diagnosis, Treatment