Investigation and influencing factors of postoperative fatigue in patients with hepatocellular carcinoma after liver transplantation

Abstract

Abstract: Objective: To investigate and analyze the incidence of fatigue in patients with hepatocellular carcinoma after liver transplantation, evaluate the applicability of multidimensional fatigue symptom inventory (MFSI) for patients and further analyze the factors affecting fatigue.
Method: The patients with hepatocellular carcinoma after liver transplantation who were followed up in the hepatobiliary surgery outpatient department of Beijing Chaoyang Hospital during December 2021 were selected for questionnaire survey. The fatigue of patients was evaluated by MFSI, the reliability and validity of the scale were evaluated, and the influencing factors of fatigue were further analyzed by multiple linear regression.
Result: The total MFSI score of patients with hepatocellular carcinoma after liver transplantation was 12.5±7.0, including general fatigue was 5.3±2.6, physical fatigue was 7(6, 9), emotional fatigue was 3(0, 5), psychological fatigue was 4(2, 5) and vitality was 6.7±3.2. The Cronbach's α coefficient of MFSI total score is 0.803 and the Kaiser-Meyer-Olkin (KMO) coefficient is 0.808. The results of regression analysis showed that the years after transplantation, rejection and tumor recurrence were the significant influencing factors of fatigue in patients with hepatocellular carcinoma after liver transplantation (P<0.05).
Conclusion: MFSI has good reliability and validity, and is helpful to comprehensively evaluate the fatigue status of patients with hepatocellular carcinoma after liver transplantation. Years after transplantation, rejection and tumor recurrence are the significant influencing factors of fatigue in patients with hepatocellular carcinoma after liver transplantation.

Key words: Hepatocellular carcinoma, Liver transplantation, Fatigue, Influence factor, Multidimensional fatigue symptom inventory

Wei Wei, Cui Chen, Liu Xiulian, Han Guijie, Pan Jing, Gao Yanping, Zhang Jingjing, Wang Yuan. Investigation and influencing factors of postoperative fatigue in patients with hepatocellular carcinoma after liver transplantation[J]. Electronic Journal of Liver Tumor, 2022, 9(3): 22-26.

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