肝癌肝移植患者术后疲乏的现状调查及影响因素分析

摘要/Abstract

摘要： 目的调查分析肝癌肝移植患者术后疲乏的发生现状,评估多维度疲乏症状量表（multidimensional fatigue symptom inventory,MFSI）评价肝癌肝移植患者术后疲乏的适用性,并分析肝癌肝移植患者术后疲乏的影响因素。
方法：选择2021年12月在北京朝阳医院肝胆外科门诊随诊的肝癌肝移植患者进行问卷调查,采用MFSI评估患者术后疲乏情况。采用Cronbach α系数和探索性因子分析评估MFSI评价肝癌肝移植患者术后疲乏的信度和效度,并采用多重线性回归进一步分析肝癌肝移植患者术后疲乏的影响因素。
结果：肝癌肝移植患者MFSI总分平均（12.5±7.0）分,其中一般疲乏维度平均（5.3±2.6）分,身体疲乏维度平均7（6,9）分,情绪疲乏维度平均3（0,5）分,心理疲乏维度平均4（2,5）分,活力维度平均（6.7±3.2）分。MFSI总分的Cronbach α系数为0.803,凯撒·迈耶·奥尔金（Kaiser-Meyer-Olkin,KMO）系数为0.808。多重线性回归分析结果显示,移植年限、排斥反应和肿瘤复发是肝癌肝移植患者术后疲乏的影响因素（P<0.05）。
结论：肝癌肝移植患者术后疲乏普遍存在。MFSI用于评估肝癌肝移植患者术后疲乏具有良好的信度和效度。移植年限、排斥反应和肿瘤复发是肝癌肝移植患者疲乏的显著影响因素。

关键词: 肝细胞癌, 肝移植, 疲乏, 影响因素, 多维度疲乏症状量表

Abstract: Objective: To investigate and analyze the incidence of fatigue in patients with hepatocellular carcinoma after liver transplantation, evaluate the applicability of multidimensional fatigue symptom inventory (MFSI) for patients and further analyze the factors affecting fatigue.
Method: The patients with hepatocellular carcinoma after liver transplantation who were followed up in the hepatobiliary surgery outpatient department of Beijing Chaoyang Hospital during December 2021 were selected for questionnaire survey. The fatigue of patients was evaluated by MFSI, the reliability and validity of the scale were evaluated, and the influencing factors of fatigue were further analyzed by multiple linear regression.
Result: The total MFSI score of patients with hepatocellular carcinoma after liver transplantation was 12.5±7.0, including general fatigue was 5.3±2.6, physical fatigue was 7(6, 9), emotional fatigue was 3(0, 5), psychological fatigue was 4(2, 5) and vitality was 6.7±3.2. The Cronbach's α coefficient of MFSI total score is 0.803 and the Kaiser-Meyer-Olkin (KMO) coefficient is 0.808. The results of regression analysis showed that the years after transplantation, rejection and tumor recurrence were the significant influencing factors of fatigue in patients with hepatocellular carcinoma after liver transplantation (P<0.05).
Conclusion: MFSI has good reliability and validity, and is helpful to comprehensively evaluate the fatigue status of patients with hepatocellular carcinoma after liver transplantation. Years after transplantation, rejection and tumor recurrence are the significant influencing factors of fatigue in patients with hepatocellular carcinoma after liver transplantation.

Key words: Hepatocellular carcinoma, Liver transplantation, Fatigue, Influence factor, Multidimensional fatigue symptom inventory

魏炜, 崔臣, 刘秀连, 韩桂杰, 潘晶, 高艳平, 张晶晶, 王苑. 肝癌肝移植患者术后疲乏的现状调查及影响因素分析[J]. 肝癌电子杂志, 2022, 9(3): 22-26.

Wei Wei, Cui Chen, Liu Xiulian, Han Guijie, Pan Jing, Gao Yanping, Zhang Jingjing, Wang Yuan. Investigation and influencing factors of postoperative fatigue in patients with hepatocellular carcinoma after liver transplantation[J]. Electronic Journal of Liver Tumor, 2022, 9(3): 22-26.

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