肝动脉灌注化疗治疗结直肠癌肝转移的研究进展

摘要/Abstract

摘要： 约50%的结直肠癌（CRC）患者在病程中发展出肝转移。目前,肝转移已经成为决定CRC患者长期预后的关键因素,多项研究结果显示结直肠癌肝转移（CRLM）的预后较差。多年来,肝动脉灌注化疗（HAIC）被多项国内外指南推荐应用于CRLM的治疗,并且有多项前瞻性Ⅱ、Ⅲ期临床研究和大样本回顾性研究显示了HAIC联合或不联合系统治疗在CRLM中的有效性和安全性。本综述将结合相关文献及临床应用经验,阐述HAIC在CRLM治疗中的研究进展,包括技术要点、药物选择、HAIC在可切除肝转移的术后辅助治疗、不可切除肝转移的术前转化治疗、晚期不可切除肝转移的一线治疗及后线挽救治疗中的价值,为HAIC在CRLM治疗中的临床应用提供参考。

关键词: 结直肠癌肝转移, 肝动脉灌注化疗, 临床应用, 研究进展

Abstract: Approximately 50% of patients with colorectal cancer (CRC) develop liver metastases during the course of their disease. Liver metastases have become a key determinant of long-term prognosis in patients with CRC, and multiple studies have demonstrated the poor prognosis of patients with colorectal cancer liver metastases (CRLM). In recent years, hepatic arterial infusion chemotherapy (HAIC) has been recommended by multiple Chinese and international guidelines in treating CRLM. In addition, several prospective phase Ⅱ/Ⅲ clinical trials and retrospective studies with large sample size have demonstrated the efficacy and safety of HAIC, either alone or in combination with systemic therapy, for patients with CRLM. Based on the available literature and clinical experience, this review summarizes recent advances in HAIC for CRLM, including technical essentials, drug selection, and its clinical value as adjuvant therapy for resectable liver metastases, conversion therapy for initially unresectable liver metastases, first-line therapy for advanced unresectable liver metastases, and salvage therapy. This review aims to provide a practical reference for the clinical application of HAIC in treating CRLM.

Key words: Colorectal cancer liver metastases, Hepatic arterial infusion chemotherapy, Clinical application, Research progress

樊晓雨, 郑康炼, 王晓东. 肝动脉灌注化疗治疗结直肠癌肝转移的研究进展[J]. 肝癌电子杂志, 2026, 13(3): 40-50.

Fan Xiaoyu, Zheng Kanglian, Wang Xiaodong. Advances in hepatic arterial infusion chemotherapy for colorectal liver metastases[J]. Electronic Journal of Liver Tumor, 2026, 13(3): 40-50.

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