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Molecular characterization of KRAS G12C mutation in the tumors of digestive system Zhao Tingqi, Dong Lin, Ying Jianming, Li Weihua Electronic Journal of Liver Tumor    2024, 11 (1): 4-8.   Abstract （40）      PDF （1777KB）（23）       Knowledge map    Save Objective: To identified the molecular characteristics of KRAS G12C mutation in the tumors of digestive system. Methods: Data of 1 100 patients diagnosed as digestive malignant tumor in Cancer Hospital of Chinese Academy of Medical Sciences from 2017 to 2022 were collected. The microsatellite status, tumor mutation burden (TMB) and KRAS, NRAS, BRAF and PIK3CA mutations were detected by next-generation sequencing in 1 100 patients with tumors of digestive system, including colorectal adenocarcinoma, duodenal adenocarcinoma, cholangiocarcinoma, gastric adenocarcinoma, ileocecal adenocarcinoma and pancreatic ductal adenocarcinoma. Results: Microsatellite instability-high (MSI-H) tumors were most common in duodenal adenocarcinoma (19%), followed by ileocecal adenocarcinoma (18%) and colorectal adenocarcinoma (10.2%). However, no MSI-H tumors were detected in the 100 cases of pancreatic ductal adenocarcinoma. TMB values also varied among different tumors of digestive system. High-TMB (≥10 mut/Mb) tumors were most common in ileocecal adenocarcinoma (24%), followed by duodenal adenocarcinoma (22%) and gastric adenocarcinoma (18.9%). KRAS mutations were detected in 452 of 1 100 (41.09%) cases, among which the most common tumor was pancreatic ductal adenocarcinoma (85.0%), followed by duodenal adenocarcinoma (56%) and ileocecal adenocarcinoma (53%). However, KRAS mutations were identified in 7.3% of gastric adenocarcinoma. KRAS G12C mutation was detected in 2.82% of all the 1 100 tumors, and only 6.9% (31/452) of all digestive tumors with KRAS mutations among which the most common tumor was ileocecal adenocarcinoma (2/9), followed by duodenal adenocarcinoma (13%) and colorectal adenocarcinoma (8.8%). However, no significant differences in gender, age, MSI and TMB status were observed between patients with KRAS G12C mutation and other KRAS mutation subtypes. Conclusions: Although nearly half of patients with digestive malignancies carry KRAS mutations, but only 6.9% of KRAS-mutant cases harbored KRAS G12C mutation subtype. KRAS G12C mutation was most common in ileocecal cancer, duodenal cancer and colorectal cancer. And no obvious difference in clinical and molecular pathological features compared with other types of KRAS mutations Reference | Related Articles | Metrics

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Efficacy and safety of bevacizumab with nab-paclitaxel and tegafur gimeracil oteracil potassium capsule (S-1) in advanced biliary tract adenocarcinoma Zhang Chao, Sun Yongkun, Su Aijiang, Zhao Jianjun, Zhou Jianguo, Li Zhiyu, Zhou Hua, Zhao Pan, Chen Nan, Liu Na Electronic Journal of Liver Tumor    2024, 11 (2): 61-65.   Abstract （39）      PDF （2199KB）（18）       Knowledge map    Save Objective: To evaluate the efficacy and safety of bevacizumab with nab-paclitaxel and tegafur gimeracil oteracil potassium capsule (S-1) in advanced biliary tract adenocarcinoma patients. Method: Totally 22 stageⅣ biliary tract adenocarcinoma patients were enrolled in this single arm, single center prospective phaseⅡ study. Patients were treated with bevacizumab at a dose of 5 mg/kg on day 1, nab-paclitaxel at a dose of 150 mg/m2 on day 1 and S-1, 40 to 60 mg bid/day on days 1-10 of a 14-day cycle. Treatments were repeated until disease progression or unacceptable toxicity occurred. The primary endpoint was objective response rate (ORR). The secondary endpoints were median progression-free survival (PFS), disease control rate (DCR), and adverse events (AEs). Result: The number of patients enrolled were 22, and 21 patients were evaluated for efficacy, with a median of 6 cycles of treatment and a median of 2 lines of treatment. A total of 9 patients achieved partial response (PR) with an ORR of 42.9%(9/21), DCR was 85.7%(18/21). 3 progressive disease was observed. The median PFS were 8 months (95% confidence interval [95%CI]: 4.5~11.5). The incidence of grade 3 treatment-related adverse events in 22 patients was 68.2%(15/22), and there were no grade 4 treatment-related adverse events. The most common grade 3 or 4 toxicities were neutropenia (18.1%), Thrombocytopenia in 2 cases (9.1%), gastrointestinal reaction in 2 cases (9.1%), increased total bilirubin (TBIL)/direct bilirubin (DBIL) in 1 case (4.5%), anemia in 1 case (4.5%), others including neurotoxicity, elevated aminotransferase, bleeding, diarrhea, fatigue, elevation of blood pressure, proteinuria, etc., were grade 1 to 2. During treatment, 4 cases (18.1%) were combined with infection, 3 cases stopped treatment due to adverse events, and there were no treatment-related deaths. Conclusion: The combination of bevacizumab with nab-paclitaxel and S-1 showed explicit antitumor activities and favorable safety profile in advanced biliary tract adenocarcinoma patients, which has good clinical therapeutic value. Reference | Related Articles | Metrics

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Clinical application of computerized tomography-guided microwave ablation in the treatment of hepatitis B-related hepatocellular carcinoma oligosenterinoma Hu Caixia, Zhao Peng, Liu Bojun, Yang Xiaozhen, Fang Da, Zheng Jiasheng, Zhang Yonghong Electronic Journal of Liver Tumor    2024, 11 (1): 1-3.   Abstract （37）      PDF （1509KB）（27）       Knowledge map    Save Objective: To evaluate the efficacy, safety and application value of microwave ablation for patients with liver cancer associated with hepatitis B and lung metastases in the era of pre-target immunotherapy. Methods: From November 2010 to December 2014,30 patients (24 males and 6 females) with pulmonary metastases were treated by microwave ablation Age ranged from 35 to 74 years, with a median age of 57.1 years. 67 pulmonary metastases were detected by chest CT and 67 lesions were ablated. The diameter of the tumor ranged from 0.5 cm to 4.1 cm in 9 patients with single lesion, 5 patients with 2 lesions and 16 patients with 3 lesions, the average diameter was 1.37 cm. Kaplan-meier method was used to calculate local tumor control rate, median survival time and complications. Results: Microwave ablation was successfully performed 46 times in 67 cases of liver cancer with lung metastases. One to three months after ablation, enhanced CT showed no enhancement in the target area. The complete ablation rate was 100% , and the median survival time was 27.5 months, the main complications included local pain (6 cases) , paroxysmal cough (13 cases) and a small amount of hemoptysis (3 cases) , 10 patients developed mild pneumothorax without special treatment, and 3 patients developed moderate to severe pneumothorax. Immediate closed chest drainage was performed. Conclusion: CT-guided microwave ablation is a safe and effective method for the treatment of lung metastases from hepatitis B-related liver cancer. Reference | Related Articles | Metrics

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Research progress of lenvatinib for hepatocellular carcinoma Pei Xirui, Li Xiaohang Electronic Journal of Liver Tumor    2024, 11 (1): 25-29.   Abstract （37）      PDF （1617KB）（19）       Knowledge map    Save Hepatocellular carcinoma is a major challenge affecting global health and has been recognised as a leading cause of death both in China and the world. Due to its insidious, rapidly progressive and highly malignant nature, many patients with hepatocellular carcinoma have already lost their chance of surgery by the time they are diagnosed. Lenvatinib has the ability to inhibit the growth of both tumor cells and tumor angiogenesis, which results in a better effect on patients with unresectable hepatocellular carcinoma and significantly prolongs the overall survival of patients. Therefore, lenvatinib is considered as a first-line target drug for the treatment of unresectable hepatocellular carcinoma. This article presents a systematic review about the research progress of lenvatinib for hepatocellular carcinoma and future perspectives. Reference | Related Articles | Metrics

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Prognosis and risk factors of different recurrence patterns after hepatectomy for colorectal liver metastasis Chen Hanwei, Li Lei Electronic Journal of Liver Tumor    2024, 11 (2): 27-32.   Abstract （36）      PDF （3700KB）（14）       Knowledge map    Save Objective: To study the prognostic differences and risk factors of different recurrence patterns after hepatectomy for colorectal liver metastasis. Methods: The general data, clinical data and follow-up data of patients with colorectal liver metastasis who underwent hepatectomy in the Department of General Surgery of Peking University Third Hospital from January 2009 to February 2023 were collected. Kaplan-Meier curve was used to analyze the survival differences between different recurrence times and different recurrence sites. The maximally selected test was used to find the optimal cut-off value of recurrence time for distinguishing the survival after recurrence. Logistic regression analysis were used to analyze the risk factors of early recurrence. Results: A total of 281 patients met the inclusion and exclusion criteria. There were statistically significant differences in mortality and overall survival between patients with and without postoperative recurrence (P=0.001). The optimal cut-off value for distinguishing early and late recurrence was 12 months (P=0.001). There was a statistically significant difference in the post-recurrence survival between patients with early recurrence and late recurrence (P=0.001 1). There was a statistically significant difference in the post-recurrence survival between different recurrence sites (P=0.002 3), and the prognosis of patients with the first recurrence site in the lung was the best. Logistic regression analysis showed that patients with positive lymph node metastasis of primary tumor (OR=2.294, 95%CI:1.171-4.496, P=0.019), preoperative CEA≥5.31 ng/ml (OR=2.160, 95%CI:1.001-4.660, P=0.049 8) and preoperative CA19-9≥ 40.52 U/ml (OR=2.210, 95%CI:1.030-4.741, P=0.042) were at high risk of early recurrence after surgery. Conclusions: The recurrence within 12 months and extrapulmonary recurrence is associated with poor prognosis. The risk factors for early recurrence include positive lymph node metastasis of primary tumor, preoperative CEA≥5.31 ng/ml and preoperative CA19-9≥ 40.52 U/ml. Patients with related risk factors should be actively reviewed and monitored. Reference | Related Articles | Metrics

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Clinical application progress of circulating tumor cells for accurate dynamic monitoring of hepatocellular carcinoma Huang Xiaozhun, Wang Fuzun, Xie Yunliang, Ran Yihong, Xu Lin, Huang Zhangkan, Yin Xin, Bi Xinyu, Che Xu Electronic Journal of Liver Tumor    2024, 11 (1): 21-24.   Abstract （35）      PDF （1596KB）（19）       Knowledge map    Save Hepatocellular carcinoma (HCC) is the fifth most common neoplasm and a major cause of cancer-related death worldwide. There is no ideal biomarker allowing early diagnosis of HCC and tumor surveillance in patients receiving therapy. Circulating tumor cells (CTC) have become a useful tool for diagnosing and monitoring therapeutic responses of different tumors in a non-invasive setting, and have great potential for precision medicine delivery in HCC patients. Based on existing clinical application evidence, this review will discuss the application and research progress of CTC in guiding surgical methods, resection margins, interventional therapy and systematic therapy, and other accurate dynamic monitoring. Reference | Related Articles | Metrics

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Analysis of clinical features of multiple primary tumors associated with liver cancer Wu Wenqi, Wang Hao, Wang Yuxia Electronic Journal of Liver Tumor    2024, 11 (2): 33-36.   Abstract （32）      PDF （1988KB）（8）       Knowledge map    Save Objective: To explore the clinical epidemiological characteristics and survival outcomes of patients with multiple primary malignant tumors (MPMTs) combined with liver cancer. Methods: From August 2010 to June 2023, patients with liver cancer were selected from malignant tumor patients admitted to the Cancer Center of Peking University Third Hospital. The basic information of the patients and the incidence information of liver cancer and other tumors were collected to make comparisons between MPMTs and single liver cancer, also groups with liver cancer as the first or the second primary cancer. Results: The incidence of liver cancer combined with extraneous tumors was accounting for 13.1% (23/176) of liver cancer patients during the same period. Among the patients, 5 had synchronous multiple primary tumors, and 18 had metachronous multiple primary tumors. Of these patients, 9 had liver cancer as the first primary tumor, and 9 had liver cancer as the second primary tumor. Liver cancer patients with family history of cancer were more likely to have multiple primary tumors (χ2=5.22, P=0.030). Liver cancer as the first primary tumor had a shorter interval for multiple primary tumor onset compared to liver cancer as the second primary tumor (35 month vs. 156 month, P=0.009). The onset interval was negatively correlated with the diagnosis age of the first primary tumor (r=-0.60, P=0.009). Conclusions: Multiple primary tumors associated with liver cancer tend to occur in patients with a family history of cancer. There was a difference in the tumor incidence interval between multiple primary cancers with liver cancer as the first primary tumor and multiple primary cancers with liver cancer as the second primary tumor. Reference | Related Articles | Metrics

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Effect of targeted nursing management on patients with liver cancer after radiotherapy Du Mengya, Chen Peijuan, Sun Jingyuan Electronic Journal of Liver Tumor    2024, 11 (1): 34-37.   Abstract （32）      PDF （1597KB）（10）       Knowledge map    Save Objective: To explore the intervention effect of targeted nursing in radiotherapy of liver cancer patients. Methods: From October 2017 to October 2019, 208 patients with liver cancer undergoing radiotherapy in our hospital were selected and randomly divided into control group (106 cases) and experimental group (102 cases). The two groups were given targeted nursing and routine nursing respectively. Baseline data were compared between the two groups, as well as visual analog pain scores, anxiety and depression scores, quality of life scores, complication rate, compliance, and satisfaction with care. Results: There was no significant difference in visual analog pain scores, anxiety and depression scores, and quality of life scores between the two groups before the targeted intervention (all P> 0.05). After 3 months of care, the visual analog pain, anxiety, depression and quality of life were higher than the control group (all P<0.05); the complication rate was lower than the control group (9.8% vs 30.2%, P<0.05), and the compliance was better than the control group (96.07% vs 84.91%, P<0.05); the nursing satisfaction was higher than the control group (all P<0.05). Conclusion: Targeted nursing can reduce the complications of patients with liver cancer radiotherapy, improve the overall satisfaction of patients. Reference | Related Articles | Metrics

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Research progress on conversion therapy for patients with malignant liver tumors with inadequate remnant liver volume Li Xin, Li Zhiyu Electronic Journal of Liver Tumor    2024, 11 (1): 16-20.   Abstract （32）      PDF （1646KB）（25）       Knowledge map    Save For patients with primary or locally metastatic malignant liver tumors,the only chance for long-term survival is complete resection of the liver tumors. However, post-hepatectomy liver failure(PHLF) remains a major cause of mortality after liver resection,and inadequate future liver remnant has been proven to be a major risk factor for PHLF. Currently,various methods exist for preoperative conversion therapy. Portal vein embolization and associating liver partition and portal vein ligation for staged hepatectomy are the two most widely used methods. However, each method has its distinct advantages and disadvantages. With the development of comprehensive treatment for malignant tumors, several treatment methods are under exploration. This study compares different conversion therapy methods,aiming to provide clinical references. Reference | Related Articles | Metrics

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Global liver and gallbladder cancer incidence and mortality in 2022 and projections to 2050 Liu Manqi, Xu Mengyuan, Shan Tianhao, Zhao Hong, Zeng Hongmei, Cai Jianqiang Electronic Journal of Liver Tumor    2024, 11 (2): 53-60.   Abstract （30）      PDF （2821KB）（12）       Knowledge map    Save Objective: To analyze the global epidemiological profiles of liver and gallbladder cancer in 2022, and project the global burden of cancer incidence and mortality until 2050. Methods: Based on the GLOBOCAN 2022 database, we analyzed the global burden of liver and gallbladder cancer in 2022 and the projected disease burden in 2050. We calculated age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs) by using Segi's world standard population structure data. We estimated the future number of cases and deaths by 2050 based on world population prospects. Results: In 2022, there were an estimated 866,136 new cases and 758,725 deaths from liver cancer, corresponding to ASIRs and ASMRs of 8.6 per 100,000 and 7.4 per 100,000, respectively. There were an estimated 122,491 new cases and 89,055 deaths from gallbladder cancer, corresponding to ASIRs and ASMRs of 1.2 per 100,000 and 0.83 per 100,000, respectively. Incidence and mortality rates of liver cancer were higher in males than in females across different age groups, and gallbladder cancer displayed higher rates among females compared to males. The country with the highest ASIR and ASMR for liver cancer was Mongolia. For gallbladder cancer, Bolivia reported the highest ASIR and ASMR. By 2050, the annual number of new cases and deaths from liver cancer will increase to 1,564,034 (an 80.6 percent increase from the year 2022) and 1,420,926 (an 87.3 percent increase), respectively. The annual number of new cases and deaths from gallbladder cancer will increase to 235,096 (a 91.9 percent increase from the year 2022) and 176,725 (a 98.4 percent increase), respectively. Africa has the largest increase in both projected new cases and deaths from liver and gallbladder cancer globally in 2050. Conclusions: Inequities in liver and gallbladder disease burden persist worldwide. Regions such as Asia and Africa, as well as countries such as Mongolia and Bolivia, which face heavy disease burden and rising incidence rates, must prioritize the establishment of cancer control initiatives. Reference | Related Articles | Metrics

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Research progress in the liquid biopsy in hepatocellular carcinoma Liang Renshan, Zhang Yu, Chen Zutao, Feng Tingting Electronic Journal of Liver Tumor    2024, 11 (1): 30-33.   Abstract （28）      PDF （1660KB）（11）       Knowledge map    Save At present, primary hepatocellular carcinoma ranks fourth common malignant tumor and second tumor cause of death in China, seriously threatening the pubic life and health.Because of its hidden incidence and non-specific clinical manifestations, the early diagnosis rate of primary liver cancer is low.When liver cancer is found,the condition often have progressed to the advanced stage and the prognosis is very poor.Therefore, modern medicine there is an urgent need for new detection methods to early diagnosis, real-time monitoring and effective treatment of liver cancer."Liquid biopsy" is one of the new detection methods.Many studies have shown that liquid biopsy is of great significance in the early diagnosis, targeted treatment, metastasis, recurrence and prognostic evaluation of liver cancer. The purpose of this review is to briefly introduce the research progress of liquid biopsy in hepatocellular carcinoma. Reference | Related Articles | Metrics

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Electronic Journal of Liver Tumor    2024, 11 (1): 47-49.   Abstract （27）      PDF （1635KB）（16）       Knowledge map    Save Related Articles | Metrics

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Electronic Journal of Liver Tumor    2024, 11 (1): 42-46.   Abstract （25）      PDF （6972KB）（20）       Knowledge map    Save Reference | Related Articles | Metrics

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Effect of hepatic R1 margin on intrahepatic recurrence of colorectal cancer liver metastases Ai Xiangnan, Wang Hangyan, Zhang Wenxuan, Jin Changguo, Wu Zhenyu, Xiu Dianrong Electronic Journal of Liver Tumor    2024, 11 (2): 37-42.   Abstract （24）      PDF （2323KB）（3）       Knowledge map    Save Objective: The effect of R1 margin on liver resection for colorectal cancer liver metastasis (CRLM) has been controversial, and there is a lack of models for the effect of hepatic R1 margin on intrahepatic margin recurrence. This study aimed to construct a predictive model for intrahepatic margin recurrence in CRLM patients to understand whether there is an effect of R1 margin on intrahepatic margin recurrence. Methods: The data of 123 CRLM patients undergoing surgical treatment in the General Surgery Department of Peking University Third Hospital from January 2009 to December 2020 were retrospectively analyzed, and the factors with independent predictive value for intrahepatic margin recurrence were established through binary Logistic regression analysis, and the predictive model was established. Results: The whole cohort had 48 (39.0%) and 75 (61.0%) non-hepatic recurrence.73 (59.3%) of R0 resection and 50 (40.7%) of R1 resection. In the univariate regression analysis, the maximum diameter of metastases (OR=2.396, P=0.041), non-anatomical resection (OR=3.732, P=0.025), operation duration (OR=2.571, P=0.013), liver R1 margin (OR=2.907, P=0.005) were significantly associated with hepatic R. margin recurrence. After multivariate regression analysis, R1 margin was no longer statistically significant (OR=2.103, 95%CI: 0.94-4.65, P=4.70), while metastasis with maximum diameter >21 mm (OR=2.509, 95%CI: 1.02-6.17, P=0.045) and non-anatomical resection (OR=3.585, 95%CI: 1.06-12.15, P=0.040) had independent predictive value for intrahepatic margin recurrence. Conclusions: The R1 margin in the model established in this study seemed to increase the risk of intrahepatic margin recurrence, but did not reach statistical significance. Independent risk factors affecting intrahepatic margin recurrence were the maximum diameter of hepatic metastases and non-anatomical resection. Reference | Related Articles | Metrics

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A Meta-analysis of the curative effect and safety of transcatheter arterial chemoembolization combined with radiofrequency ablation in the treatment of large liver cancer Li Mei, Qiao Bei, Zhang Zhihao Electronic Journal of Liver Tumor    2024, 11 (1): 9-15.   Abstract （24）      PDF （7001KB）（15）       Knowledge map    Save Objective: Through Meta-analysis, compared with transcatheter arterial chemoembolization (TACE) alone, to analyze the curative effect and safety of TACE combined with radiofrequency ablation (RFA) in treating large liver cancers. Method: According to the Meta-analysis process, the relevant domestic and foreign related databases such as PubMed, Embase, Seer, Cochrane Library, CNKI, Wanfang Medical Network, VIP, China Biomedical Literature Database were searched with defined search terms. The search period was January 2003 to June 2023. Randomized controlled clinical studies on the efficacy and safety of TACE+RFA versus TACE alone in the treatment of large liver cancer were screened and included. The quality of the included studies was evaluated and Meta-analysis was performed using RevMan5.4 software. Result:Finally, A total of 16 papers were included, involving 1 175 patients, including 587 cases in the TACE+RFA group and 588 cases in the TACE alone group. The results of Meta-analysis indicated that: compared with the TACE alone group, the objective response rate (ORR) [relative risk (RR)=1.46, 95% confidence interval (95%CI): 1.35-1.59, P<0.000 01], disease control rate (DCR) (RR=1.17, 95%CI: 1.12-1.22, P<0.000 01), 1-year survival rate (RR=1.39, 95%CI: 1.24-1.55, P<0.000 01), 2-year survival rate (RR=1.79, 95%CI: 1.38-2.32, P<0.000 1) and 3-year survival rate (RR=3.20, 95%CI: 1.25-8.20, P=0.02) of TACE+RFA group were better than those of simple TACE group, and the difference was statistically significant. There was no significant difference in the common adverse reactions between the two groups. Conclusion: Compared with TACE alone, TACE+RFA can improve the short-term efficacy and the long-term survival rate of large liver cancer patients, and does not increase the occurrence of adverse reactions. Reference | Related Articles | Metrics

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Study on the development trend of liver cancer mortality among Chinese residents from 2012 to 2021 Shao Tang, Zheng Fangshu, Wu Jun Electronic Journal of Liver Tumor    2024, 11 (3): 54-57.   Abstract （24）      PDF （1992KB）（8）       Knowledge map    Save Objective: To analyze the trends of liver cancer mortality and standardized mortality among Chinese residents from 2012 to 2021. Methods: The trend of liver cancer mortality and standardized mortality among Chinese residents was studied and analyzed by using the Joinpoint regression model with the number of liver cancer deaths and survey population in the National Disease Surveillance System Cause of Death Surveillance Dataset (2012), the Chinese Cause of Death Surveillance Dataset (2013-2021), and the data from the 6th and 7th national census as the study data. Results: The number of liver cancer deaths and mortality rates among men in the surveillance population from 2012 to 2021 years were approximately 2.7 to 2.8 times higher than those among women. There were 2 Joinpoint turning points for liver cancer mortality in the total, male and female populations in the surveillance population from 2012 to 2021 years, with the turning points in the male population occurring in 2014 years and 2018 years, with an increasing trend from 2012 to 2014 years (P<0.05) and a decreasing trend from 2014 to 2018 years (P<0.05). The turning points in the total and female populations occurred in 2014 years and 2019 years, with an upward trend from 2012 to 2014 years (P<0.05) and a downward trend from 2014 to 2019 years (P<0.05). There was one Joinpoint turning point of liver cancer mortality in the total population, male population and female population, which occurred in 2019 years, and the female population showed an increasing trend from 2019 to 2021 years (P<0.05). Conclusion: The mortality rate of liver cancer in the monitored population was higher in males than in females, and its development trend showed an increasing trend before 2014 and a decreasing trend after 2014, and the trend of the standardized mortality rate of liver cancer tended to be stable. Reference | Related Articles | Metrics

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Study on the development track of early fatigue after liver transplantation Xi Shuangmei, Zhang Lili, Gu Yanmei, Guo Huimin, Liu Xin, Zheng Yulin, Jin Boxun, Li Guangming Electronic Journal of Liver Tumor    2024, 11 (2): 94-99.   Abstract （22）      PDF （2176KB）（9）       Knowledge map    Save Objective: To explore the development track of early fatigue after liver transplantation and its influencing factors. Methods: 96 liver transplant patients who were followed up in the liver transplant center of our hospital from January 2019 to March 2023 were selected as the research objects. Fatigue assessment scale (FAI) was used to evaluate the fatigue of patients at 1 week, 2 weeks, 1 month, 3 months and 6 months after liver transplantation, and growth mixed model (LGMM) was used to analyze and identify the early fatigue development track of patients after liver transplantation. The general data, social support and psychological state of patients were collected, and the influencing factors of patients' early fatigue development track were analyzed by multi-classification Logistic regression. Results: During the 6-month follow-up, there were 91 patients with complete follow-up data of FAI scale, and finally 91 patients were included. LGMM analysis showed that the early fatigue development trend of patients after liver transplantation was divided into three types, namely, descending group(n=36), stable group(n=34) and ascending group(n=21). The fatigue development of all three groups had a time effect. The FAI score of descending group decreased significantly with time, while that of stable group did not change significantly with time, while that of ascending group increased significantly with time. Logistic regression analysis showed that age, anxiety, depression, sleep status and social support level were the influencing factors of early fatigue development after liver transplantation (P<0.05). Conclusion: The development track of early fatigue in patients after liver transplantation is heterogeneous, and there are different types of development trends, among which age, anxiety, depression, sleep state and social support level are the influencing factors. Reference | Related Articles | Metrics

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Clinical and pathological factors affecting the prognosis of patients with colorectal liver metastasis Wang Peng, Du Jundong, Wang Hangyan, Xiu Dianrong Electronic Journal of Liver Tumor    2024, 11 (2): 43-47.   Abstract （22）      PDF （2377KB）（5）       Knowledge map    Save Objective: To investigate the clinical and pathological factors affecting the prognosis of patients with colorectal liver metastases (CRLM) patients. Method: Patients with synchronous CRLM who were admitted to Peking University Third Hospital from March 2014 to March 2016 were retrospectively analyzed. The relevant clinical data, pathology of primary tumor and liver metastases of each patient were collected, and the patients were followed up. Univariate analysis and Cox regression were used to analyze the independent prognostic factors of CRLM. Result: A total of 97 patients with CRLM were included in this study, including 57 males and 40 females, with an average age of (61.2±11.8) years, 54 cases in the right colon and 43 cases in the left colon and rectum. Univariate analysis showed that preoperative carcinoembryonic antigen (CEA)>32 ng/ml, preoperative carbohydrate antigen19-9 (CA19-9)>20 U/ml, presence of cancer nodules, postoperative N stage, primary tumor located in the right hemicolon, the number of liver metastases>3, and poor differentiation of the primary tumor were non-independent risk factors affecting the 3-year overall survival of patients (all P<0.05). Cox regression model was used for multivariate analysis, the results showed that preoperative CEA level (hazard ratio [HR]=2.123, 95% confidence interval [95%CI]: 1.151-3.918), preoperative CA19-9 level (HR=2.022, 95%CI: 1.094-3.738), primary tumor location (HR=0.502, 95%CI: 0.265-0.951) and tumor differentiation (HR=0.519, 95%CI: 0.300-0.899) were independent risk factors for prognosis. Conclusion: The primary tumor located in the right hemicolon, the primary tumor poorly differentiated, the preoperative CEA >32 ng/ml, and the preoperative CA19-9 >20 U/ml are independent risk factors affecting the prognosis of patients with CRLM. Reference | Related Articles | Metrics

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The overexpression of miRNA-10a promotes liver regeneration in rats with liver cirrhosis after hepatectomy Yu Zhencen, Gu Xiaohui, Liu Chao, Wang Xin Electronic Journal of Liver Tumor    2024, 11 (2): 48-52.   Abstract （22）      PDF （3705KB）（8）       Knowledge map    Save Objective: To investigate the effect of miRNA-10a on liver regeneration in rats after liver resection in liver cirrhosis. Methods: Thirty-six cirrhotic rats were randomly divided into a sham operation group (Group A, n=12), a 70% liver resection without transfection group (Group B, n=12), and a 70% liver resection with transfection group (Group C, n=12). Two weeks before surgery, successful hepatocyte-specific transfection of miRNA-10a was performed in rats of Group C. At 12h, 24h, 48h, and 72h after surgery, 3 rats from each group were euthanized, and blood samples from the portal vein were collected for testing serum liver function indicators including alanine aminotransferase (ALT) and albumin (ALB). The levels of miRNA-10a in liver tissue were detected using PCR, and the liver-to-body weight ratio was calculated at different time points. Results: At 12 h, 24 h, 48 h, and 72 h after surgery, the levels of miRNA-10a in liver tissue of Group C rats were significantly higher than the other two groups, indicating successful overexpression of miRNA-10a. At 12 h, 24 h, 48 h, and 72 h after surgery, the serum ALT levels of Group C rats were lower on average than Group B, while the ALB levels were higher on average than Group B, suggesting that miRNA-10a is beneficial for protecting liver function. At 48 h and 72 h after surgery, the liver-to-body weight ratio of Group C rats was significantly higher than Group B, indicating that overexpression of miRNA-10a promotes liver tissue growth. Conclusion: Overexpression of miRNA-10a promotes liver regeneration in rats with liver cirrhosis after hepatectomy. Reference | Related Articles | Metrics

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Electronic Journal of Liver Tumor    2024, 11 (2): 1-26.   Abstract （21）      PDF （4919KB）（5）       Knowledge map    Save Related Articles | Metrics