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ERCC6L mediates DNA repair and replication signaling to promote hepatocellular carcinoma proliferation and metastasis Li Dongliang, Zhou Baofu, Du Chaogang, Wu Jing, Huang Cheng Electronic Journal of Liver Tumor    2025, 12 (3): 19-29.   Abstract （34）      PDF （10189KB）（20）       Knowledge map    Save Objective: To explore the mechanism of ERCC6L gene in hepatocellular carcinoma(HCC). Methods: The expression and prognostic differences of ERCC6L and DNA methylation levels in HCC cells were analyzed by public databases and immunohistochemistry; the effects of ERCC6L expression on HCC cells proliferation, transfer and invasion were analyzed by in vivo and in vitro experiments, and the cell cycle effects of ERCC6L on HCC cells were analyzed by flow cytometry. The effects of ERCC6L on DNA repair and replication signals (RRM1,RRM2,POLE2 and LIG1) in HCC cells were analyzed by functional enrichment and protein immunoblotting experiments. Results: ERCC6L mRNA and protein levels were up-regulated in HCC tissues (all P<0.05).The overall survival rate of HCC patients with high expression of ERCC6L was lower than that of patients with low expression (P<0.05). ERCC6L showed hypomethylation status in HCC patients,including cg01004805, cg12747864, cg09743261, cg05279113. Knockdown of ERCC6L inhibited HCC cell viability, proliferation, migration and invasive ability, and reduced HCC tumor growth (all P<0.05). The KEGG signaling pathway of ERCC6L was mainly enriched in cell cycle,DNA replication and Fanconi anemia pathways. Knockdown of ERCC6L expression induced G0/G1 phase arrest in HCC cells and decreased the levels of RRM1,RRM2,POLE2 and LIG1 protein expression (all P<0.05). Conclusion: ERCC6L is highly expressed in HCC patients and mediates worse prognosis by a potential mechanism through mediating DNA repair and replication signaling. Reference | Related Articles | Metrics

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Efficacy and safety analysis in the treatment of unresectable intrahepatic cholangiocarcinoma by transcatheter arterial chemoembolization with small diameter drug-eluting beads Xuan Zhiming, Yao Xuesong, Song Peng, Li Shupei, Lai Fengyong, Feng Yexia Electronic Journal of Liver Tumor    2025, 12 (4): 8-13.   Abstract （12）      PDF （5021KB）（10）       Knowledge map    Save Objective: To evaluate the efficacy and safety of drug-eluting beads transcatheter arterial chemoembolization (DEB-TACE) with small diameter drug-eluting beads (DEBs) in the treatment of unresectable intrahepatic cholangiocarcinoma (ICC). Method: This article retrospectively collected clinical data of 20 patients with unresectable ICC who received small diameter DEB-TACE treatment Chinese Academy of Medical Sciences and Peking Union Medical College Cancer Hospital & Shenzhen Hospital from March 2018 to December 2023. The efficacy and safety of the treatment were analyzed by evaluating indicators such as tumor response, progression free survival (PFS), overall survival (OS), incidence of adverse events, and compared the results with other literatures on conventional diameter DEB-TACE and systemic chemotherapy. Result: The 3-month objective response rate (ORR) and disease control rate (DCR) of 20 patients with unresectable ICC after DEB-TACE were 60.0% and 95.0%, respectively. The 6-month ORR and DCR were 30.0% and 75.0%, respectively. And the 9-month ORR and DCR were 10.0% and 45.0%, respectively. The median OS and median PFS were 16.4 months and 8.3 months, respectively. The common adverse events after DEB-TACE include bilirubin elevation,abdominal pain,nausea and vomiting, and aminotransferase elevation, all of which are grade 1 or 2, and there is no grade 3 or higher adverse events occurred. Conclusion: DEB-TACE with small diameter DEBs is a safe and effective local treatment for unresectable ICC patients. Compared with conventional diameter DEB-TACE and systemic chemotherapy, it has similar disease control rates ,longer survival , and lower incidence of adverse events. Reference | Related Articles | Metrics

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Clinicopathological characteristics of three cases of liver primary pleomorphic undifferentiated sarcoma and literature review Li Zhuo, Gong Lihua, Ma Peiqing, Wang Bingning, Li Jin, Lu Haizhen Electronic Journal of Liver Tumor    2025, 12 (1): 10-14.   Abstract （26）      PDF （4549KB）（10）       Knowledge map    Save Reference | Related Articles | Metrics

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Expert guidance on three-level prevention of radiation-induced liver diseases Wu Zhifeng, Zeng Zhaochong Electronic Journal of Liver Tumor    2025, 12 (2): 1-7.   Abstract （23）      PDF （1891KB）（9）       Knowledge map    Save With the improvement of the efficacy of radiotherapy (RT) for abdominal tumors such as liver cancer, the clinical contradiction between the efficacy of RT and the occurrence of radiation-induced liver diseases (RILD) has become increasingly prominent. As one of the dose-limiting complications of abdominal tumor RT, RILD currently lacks a consensus on the clinical three-level prevention. On the basis of elucidating the pathogenesis of RILD, this article summarizes the influencing factors and corresponding prevention and treatment measures of RILD prevention and treatment in three levels, and provides expert guidance, summarizes the influencing factors and corresponding measures for RILD prevention and control at three levels, with the aim of enabling clinicians to be familiar with and master the potential fatal RILD during the RT process for abdominal tumors. Reference | Related Articles | Metrics

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Study on the relationship between serum circIPO11 level and its clinicopathological characteristics and prognosis in patients with primary liver cancer Yin Yagang, Zhao Jianwen, Tian Hongwei, Wang Dingxin Electronic Journal of Liver Tumor    2025, 12 (4): 30-36.   Abstract （10）      PDF （2757KB）（8）       Knowledge map    Save Objective: To analyze the relationship between serum circIPO11 level and its clinicopathological features and prognosis in patients with primary liver cancer (PLC). Methods: From February 2020 to January 2022, 120 PLC patients (case group) and 120 healthy people (control group) were prospective selected by Tianshui First People's Hospital, and the relative expression of circIPO11 in serum of all subjects was determined by real-time fluorescence quantitative PCR.Compare the relative expression of circIPO11 in serum between the control group and the case group, and draw ROC curve to analyze the value of circIPO11 expression in predicting PLC occurrence. The relative expression of circIPO11 in serum of patients with different pathological features in the case group was compared, and the correlation between the expression of circIPO11 and clinicopathological features and prognosis was analyzed. Kaplan-Meier survival analysis and Cox regression model for multivariate prognostic analysis. Results: The relative expression of serum circIPO11 in case group was higher than that in control group (P< 0.05). The ROC curve showed that the relative expression of serum circIPO11 predicted the AUC(95%CI) of PLC to be 0.883 (0.842-0.925). Compared with PLC patients with different tumor stages, degrees of differentiation, portal vein tumor thrombus, lymph node metastasis and preoperative alpha-fetoprotein level, the difference was statistically significant (all P< 0.05). Point-column correlation showed that the relative expression of serum circIPO11 was positively correlated with portal vein tumor thrombus, lymph node metastasis and preoperative alpha-fetoprotein level in PLC patients (r=0.403,0.298,0.397, P< 0.05). Spearman correlation showed that the relative expression of serum circIPO11 was positively correlated with the tumor stage of PLC patients (r=0.328, P< 0.05) and negatively correlated with the differentiation degree (r=-0.304, P< 0.05).The overall survival rate of 120 patients with PLC was 46.7%(56/120) and the median survival time was 27.5 months (95%CI: 25.8-29.3 months). Kaplan-Meier survival analysis revealed that the median survival times were 29.7 months (95%CI: 27.3-32.2 months) in the low circIPO11 expression group and 25.3 months (95%CI: 22.9-27.7 months) in the high circIPO11 expression group. The 3-year survival rate was significantly higher in the low-expression group compared to the high-expression group (P< 0.05). Multivariate regression analysis showed that tumor stage, differentiation degree, portal vein tumor thrombus, lymph node metastasis, preoperative alpha-fetoprotein level and preoperative circIPO11 expression were independent risk factors for postoperative mortality of PLC patients (all P< 0.05). Conclusions: circIPO11 is highly expressed in serum of PLC patients, and its expression is related to pathological features such as tumor stage, degree of differentiation, lymph node metastasis and preoperative alpha-fetoprotein level, and the high expression of circIPO11 is a risk factor affecting the survival status of PLC patients after 3 years. Reference | Related Articles | Metrics

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Correlation analysis of the indocyanine green retention rate at 15 minutes and the prognosis of patients with primary liver cancer after liver resection surgery Zhang Mingming, Yang Ning, Wang Haijiao, Wang Xinran Electronic Journal of Liver Tumor    2025, 12 (4): 14-19.   Abstract （9）      PDF （2537KB）（6）       Knowledge map    Save Objective: To analyze the correlation between the indocyanine green retention rate at 15 minutes(ICG-R15) and the prognosis of liver cancer patients after liver resection surgery. Method: The clinical data of 242 patients with hepatocellular carcinoma from Xuanwu Hospital of Capital Medical University from May 2024 to March 2025 were collected. Among them, 130 cases had an ICG-R15 value less than 10%, and 112 cases had an ICG-R15 value of 10% or higher. The correlation between different ICG-R15 and surgical prognosis indicators (operation duration, intraoperative blood loss, number of intraoperative drainage tubes, hospital stay, hospital expenses, 24-hour postoperative pain score, postoperative hospital stay, discharge activities of daily living [ADL] score, postoperative liver function, postoperative liver function Child-Pugh classification, postoperative model for end-stage liver disease [MELD] score) was compared. Result: The single-factor analysis showed that there were statistically significant differences in the operation duration, intraoperative blood loss, postoperative hospital stay, discharge ADL score, postoperative liver function, postoperative liver function Child-Pugh classification, and postoperative MELD score between the two groups (all P<0.05). The multivariate logistic regression analysis revealed that the operation duration, postoperative hospital stay, postoperative liver function, postoperative liver function Child-Pugh classification, and postoperative MELD score were all correlated with the preoperative ICG-R15 level (P<0.05). Conclusion: ICG-R15 has a predictive effect on the postoperative liver function of patients with primary liver cancer. Preoperative determination of ICG-R15 levels is of great significance for evaluating liver reserve function, predicting the occurrence of postoperative liver dysfunction, and optimizing surgical treatment plans. Reference | Related Articles | Metrics

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Electronic Journal of Liver Tumor    2025, 12 (2): 54-56.   Abstract （24）      PDF （1533KB）（6）       Knowledge map    Save Related Articles | Metrics

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Nurses' experiences in maintaining peripherally inserted central venous catheter in patients with with hepatocellular carcinoma complicated by hepatitis B: a qualitative study Li Caiyun, Wang Xin, Guo Huanfei, Zhang Jiwen, Liu Yang, Zhang Wei Electronic Journal of Liver Tumor    2025, 12 (3): 45-50.   Abstract （32）      PDF （2045KB）（5）       Knowledge map    Save Objective: To explore nurses'experiences in maintaining peripherally inserted central venous catheter (PICC) for patients with hepatocellular carcinoma (HCC) complicated by hepatitis B, and to identify their perceptions and needs in the care process in order to inform improvements in clinical practice. Methods: Using purposive sampling, in-depth interviews were conducted with 15 nurses from the Department of Hepatobiliary Surgery, Cancer Hospital, Chinese Academy of Medical Sciences. Data were analyzed using Colaizzi's seven-step phenomenological method. Result: Three main themes were extracted from nurses' experiences in maintaining PICC for patients with liver cancer complicated by hepatitis B: dual pressure from occupational exposure and maintenance (including the risk of occupational exposure and maintenance difficulties in the context of complex conditions), difficulties in nurse-patient interaction (including strong emotional exhaustion of nurses and insufficient maintenance behaviors of patients), and limitations of training effectiveness. Conclusion: Nurses face multiple challenges in the process of maintaining PICC for patients with liver cancer complicated by hepatitis B. It is suggested that managers take targeted intervention measures to alleviate nurses' occupational dilemmas (such as optimizing resource allocation and guarantee, strengthening the psychological support system; establishing standardized management systems to improve nurses' PICC nursing competence; innovating educational models to meet patients' disease-related needs; and building regional electronic platforms to enhance patient compliance), and improve the quality of PICC maintenance nursing in the context of complex diseases. Reference | Related Articles | Metrics

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Electronic Journal of Liver Tumor    2025, 12 (4): 1-4.   Abstract （8）      PDF （2432KB）（4）       Knowledge map    Save Reference | Related Articles | Metrics

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The value of nutritional and inflammatory indicators in predicting the prognosis of patients with advanced hepatocellular carcinoma treated with Sintilimab combined with Bevacizumab He Huari, Xia Wangning, Tang Biao, Liu Xintao, Li Lai Electronic Journal of Liver Tumor    2025, 12 (1): 39-45.   Abstract （21）      PDF （3410KB）（4）       Knowledge map    Save Objective: To explore the value of nutritional and inflammatory indicators in predicting the prognosis of patients with advanced hepatocellular carcinoma (HCC) treated with combination therapy of Sintilimab and Bevacizumab. Method: This study is a retrospective study. Totally 85 HCC patients admitted to Yongzhou Central Hospital from January 2021 to December 2021 were selected. According to the optimal critical values of nutritional indicators (prognostic nutritional index [PNI] and hemoglobin albumin lymphocyte platelet [HALP] scores) and inflammatory indicators (monocyte to high-density lipoprotein ratio [MHR], C-reactive protein to prealbumin ratio [CPR], and C-reactive protein to lymphocyte count ratio [CLR]), patients were divided into high PNI group and low PNI group, high HALP score group and low HALP score group, high MHR group and low MHR group, high CPR group and low CPR group, and high CLR group and low CLR group. Kaplan Meier method was used to analyze the survival of advanced HCC patients with different nutritional status or inflammation levels, and log rank test was used for comparison. Single factor and multiple factor Cox regression models were used to screen risk factors for overall survival in advanced HCC patients treated with combination therapy of Sintilimab and Bevacizumab. Draw receiver operator characteristic (ROC) curves to evaluate the predictive value of nutritional and inflammatory indicators for mortality in advanced HCC patients after treatment with Sintilimab combined with Bevacizumab. Result: The disease control ratio (DCR) of the high PNI group, high HALP score group, low MHR group, low CPR group, and low CLR group were all higher than those of the low PNI group, low HALP score group, high MHR group, high CPR group, and high CLR group (84.0% vs. 65.7%, χ2=19.961, P<0.001; 84.8% vs. 66.7%, χ2=6.467, P=0.011; 87.0% vs. 64.1%, χ2=6.127, P=0.013; 92.0% vs. 65.7%, χ2=4.947, P=0.026; 84.5% vs. 63.6%, χ2=4.938, P=0.016). The overall survival of patients in the high PNI group, high HALP score group, low MHR group, low CPR group, and low CLR group was longer than that of patients in the low PNI group, low HALP score group, high MHR group, high CPR group, and high CLR group (all P<0.05). The ROC curve shows that the area under the curve (AUC) for predicting death in advanced HCC patients using PNI, HALP score, MHR, CPR, and CLR is 0.797 (95% confidence interval [95%CI]: 0.738-0.855), 0.773 (95%CI: 0.713-0.833), 0.606 (95%CI: 0.528-0.683), 0.726 (95%CI: 0.665-0.788), and 0.759 (95%CI: 0.701-0.818), respectively. The results of the multivariate Cox regression model analysis showed that PNI and HALP scores were independent protective factors affecting the prognosis of advanced HCC patients treated with combination therapy of Sintilimab and Bevacizumab, while MHR, CPR, and CLR were independent risk factors affecting the prognosis of advanced HCC patients treated with combination therapy of Sintilimab and Bevacizumab. Reference | Related Articles | Metrics

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Electronic Journal of Liver Tumor    2025, 12 (4): 53-56.   Abstract （6）      PDF （2332KB）（4）       Knowledge map    Save Related Articles | Metrics

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Nationwide analysis of current nursing practices for hepatic arterial infusion chemotherapy Liu Shuyue, Huang Zhongying, Li Jing, Zhan Zhengyin, Lei Juanjuan, Zhang Tian, Wen Zilu, Zhang Yaojun, Li Fuxia Electronic Journal of Liver Tumor    2025, 12 (4): 43-49.   Abstract （13）      PDF （2615KB）（3）       Knowledge map    Save Objective: To investigate the current status and key challenges of nursing practices for hepatic arterial infusion chemotherapy (HAIC) in China. Methods: A cross-sectional survey was conducted using the National HAIC Nursing Practice Questionnaire developed by the Integrated Nursing of Hepatobiliary Tumor Committee of the Chinese Anti-Cancer Association. From October to December 2024, 83 hospitals across 24 provinces (autonomous regions/municipalities) in China were selected via convenience sampling. The questionnaire content includes the implementation institutions and nursing management status of HAIC, HAIC treatment plans, lower limb approaches, upper limb approaches, arterial port systems, and the current status of follow-up care. Results: HAIC procedures were primarily performed in Interventional Therapy Department (96%, 80/83), with 76% (63/83) of patients managed in Hepatobiliary Department. The FOLFOX (Oxaliplatin+Calcium folinate+Fluorouracil) regimen was the dominant treatment protocol (84%, 70/83), and 52% (43/83) of hospitals combined HAIC with transcatheter arterial chemoembolization (TACE). Femoral artery access remained dominant (94%, 78/83), with 88% (73/83) requiring strictly limit bed confinement. Only 12% (10/83) permitted ambulation within 6 hours post-procedure. Upper-limb access (22%, 18/83) was valued for reducing bed rest requirements (94%) and complication risks (44%). Arterial port systems were implemented in 8% (7/83) of hospitals, but 5/7 exhibited nonstandard heparin concentrations during port maintenance.Only 40% (33/83) of hospitals provided post-discharge follow-up, predominantly via telephone (63%, 21/33) or WeChat (29%, 9/33), with intelligent management systems remaining underutilized. Conclusion: HAIC nursing in China faces challenges including nonstandard technical protocols, excessive postoperative activity restrictions, and underdeveloped continuity of care systems. Establishing evidence-based guidelines, optimizing access strategies, and advancing intelligent follow-up frameworks are urgently needed to enhance treatment efficacy and patient outcomes. Reference | Related Articles | Metrics

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Electronic Journal of Liver Tumor    2025, 12 (4): 50-52.   Abstract （11）      PDF （5901KB）（3）       Knowledge map    Save Reference | Related Articles | Metrics

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Clinicopathological features analysis of 4 cases of intrahepatic enteroblastic adenocarcinomas Hu Chunfang, Lu Haizhen, Shi Susheng Electronic Journal of Liver Tumor    2025, 12 (1): 1-4.   Abstract （21）      PDF （4689KB）（3）       Knowledge map    Save Reference | Related Articles | Metrics

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Electronic Journal of Liver Tumor    2025, 12 (4): 5-7.   Abstract （9）      PDF （2325KB）（3）       Knowledge map    Save Reference | Related Articles | Metrics

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Electronic Journal of Liver Tumor    2025, 12 (3): 51-55.   Abstract （8）      PDF （6684KB）（3）       Knowledge map    Save Reference | Related Articles | Metrics

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Efficacy and safety of lenvatinib in patients with hepatocellular carcinoma Zhou Jianguo, Wang Bingchen, Li Haocheng, Zhang Yuewei, Peng Tao, Liu Hongli, Xiang Xiaojun, Sun Chuandong, Liu Jun, Li Guangming, Li Dewei, Wang Yu, Cai Jianqiang Electronic Journal of Liver Tumor    2025, 12 (3): 1-6.   Abstract （48）      PDF （2070KB）（3）       Knowledge map    Save Objective: To evaluate the efficacy and safety of the comprehensive treatment regimen based on lenvatinib in patients with HCC. Methods: This study was a retrospective real-world study. A total of 1,000 HCC patients who received comprehensive treatment based on lenvatinib and were admitted to 13 research centers across the country from January 2022 to December 2024 were included. The basic clinical information of patients, treatment plans, laboratory indicators and survival outcomes were all collected and managed through standardized databases. The primary endpoint of the study was progression-free survival (PFS), and the secondary endpoints included the 1-year PFS rate, 1-year overall survival rate (OS), and safety analysis. Statistical analysis was conducted using Kaplan-Meier survival analysis and log-rank test to evaluate the differences in efficacy among different treatment strategies. Results: Among 1 000 patients, 83.70% were male, and the median age was 59.0 years (IQR: 52.0, 67.0). In the analysis of the combined disease history of the patients, the disease distribution showed significant differences: The proportion of history of hypertension was the highest (15.60%), followed by history of diabetes (5.80%), and liver cirrhosis (5.00%). The proportion of patients who had received surgical treatment in the past was 30.50%, the proportion of liver resection was 19.50%, and only 1.80% of the patients had received radiotherapy. The application rate of interventional therapy in the population of this study was 34.60%. The positive rate of hepatitis B virus surface antigen was 55.10% and the positive rate of anti-hepatitis C virus antibody was 3.80%. According to the Barcelona Clinic Liver Cancer(BCLC) staging, the proportion of patients in the advanced stage (BCLC-C, D stage) was 28.00%. In terms of treatment regimens, 79.80% of the patients received 8mg lenvatinib treatment, 60.7% of the patients received lenvatinib monotherapy, and 20.8% of the patients received combined immunotherapy. The therapeutic effect analysis showed that the median PFS of the overall patients was 7.0 months (95%CI: 7.0-8.0), and the 1-year OS rate was 97.00%(95%CI: 96.00%-98.00%). The 1-year PFS rate was 16.00%(95%CI: 14.00%-19.00%). The adverse events occurred rate was 23.60% during the follow-up period, and no serious adverse events were observed. Conclusion: The lenvatinib combination strategy has a positive impact on survival prognosis for HCC patients, but it still needs to be optimized for long-term disease control. Reference | Related Articles | Metrics

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Current status and prospects of artificial intelligence and 5G technology in synergistic medical-educational application in hepatic surgery Sheng Jiyao, Wen Xin, Wang Zhenxiao, Liu Shui, Zhang Xuewen Electronic Journal of Liver Tumor    2025, 12 (3): 36-40.   Abstract （15）      PDF （1984KB）（2）       Knowledge map    Save Hepatic surgery, characterized by complex anatomy and high surgical risks, confronts predicaments in clinical practice including uneven distribution of medical resources, insufficient surgical precision, and low efficiency in remote collaboration in clinical practice. In the field of education, it encounters problems such as abstract and hard-to-understand knowledge, scarce practical opportunities, and unbalanced resource distribution. The deep integration of artificial intelligence (AI) and fifth-generation communication technology (5G) offers a potential solution to these problems. The application of AI and 5G in the medical and educational collaboration of liver surgery is expected to achieve the future development goals of high precision, wide coverage, and strong inheritance in liver surgery through new ideas, methods, and technologies of medical and educational collaboration. Moreover, by leveraging innovative technological transformation means, it can broaden the dimension of technological innovation and enhance the breadth of technological application, playing a greater role in the future medical and educational collaboration of liver surgery. Reference | Related Articles | Metrics

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Effect and mechanism analysis of low-dose ETO in adjuvant to PRO anesthesia induction for postoperative prognosis of hepatocellular carcinoma Zhai Rui, Yu Lichun, Li Hongxiang, Zhai Yongya Electronic Journal of Liver Tumor    2025, 12 (4): 20-29.   Abstract （5）      PDF （4782KB）（2）       Knowledge map    Save Objective: To analyze the prognostic impact of low-dose etomidate (ETO) assisted propofol (PRO) induction of total intravenous anesthesia on patients with hepatocellular carcinoma (HCC) and to explore the underlying biological mechanisms. Methods: Eighty-four HCC patients admitted to our hospital from January 2021 to January 2023 were selected. The patients were divided into a control group (n=42) and an experimental group (n=42) according to the randomized numerical table method; the control group was induced by PRO total intravenous anesthesia, and the experimental group was induced by a small dose of ETO-assisted PRO total intravenous anesthesia. The Kaplan-Meier method was employed for survival analysis.The relationship between ETO and the prognosis of HCC patients was determined by univariate and multivariate Cox regression model. Potential biological mechanisms of ETO in HCC radical resection patients were explored by bioinformatics, microarray data, enzyme-linked immunosorbent assay and molecular docking and kinetic modeling.The relationship between ETO and the prognosis of HCC patients was determined by univariate and multivariate Cox regression model. Results: The recurrence-free survival and overall survival of patients in the experimental group were higher than those of patients in the control group (all P<0.05). Cox regression model analysis showed that ETO was an independent protective factor for recurrence and death in HCC patients (all P<0.05), and tumor stage and CD34 were independent risk factors for recurrence and death in HCC patients (all P<0.05). The results of microarray data showed a total of 143 differentially expressed genes, which were mainly enriched in signaling pathways such as negative regulation of hematopoietic progenitor cell differentiation, mechanistic target of rapamycin(mTOR), p53, vascular endothelial growth factor A and vascular endothelial growth factor receptor 2(VEGFA ,VEGFR2), and interleukin-24(IL-24). The PPI network confirmed that CD34 was a core target gene of ETO anti-HCC. Molecular docking and kinetic modeling confirmed that ETO could bind stably to CD34 protein with a binding free energy of -29.278 kJ/mol.Cox regression model analysis showed that ETO was an independent protective factor for recurrence and death in HCC patients (all P<0.05), and tumor stage and CD34 were independent risk factors for recurrence and death in HCC patients (all P<0.05). Conclusion: Small-dose ETO-assisted PRO total intravenous anesthesia induction regimen in patients undergoing radical resection for HCC improves prognosis better and may be related to modulation of CD34 expression. Reference | Related Articles | Metrics

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Study on the correlation between collimator angles and dosimetry in stereotactic radiotherapy planning for liver cancer Dai Wanting, Dong Yu, Wang Qiushi, Fan Pengfei, Li Yuheng, Wu Dengbin Electronic Journal of Liver Tumor    2025, 12 (4): 37-42.   Abstract （7）      PDF （4663KB）（2）       Knowledge map    Save Objective: To study the dosimetric effect of different collimator angle on stereotactic radiotherapy (SRT) for liver cancer, providing a reference for collimator angle selection in clinical SRT plan design for liver cancer. Methods: A retrospective analysis was conducted on 20 liver cancer patients treated with SRT from 2018 to 2024. Nine plans were generated with collimator angles ranging from 0°/0° to 80°/280° at 10° intervals, under identical planning parameters. The Friedman test was used to compare differences in conformity index (CI), gradient index (GI), normal liver V10/V20/V30, mean liver dose, 0.03 cm3 spinal cord dose (D0.03 cm3 ), monitor units, and γ pass rate (3%/2mm standard). Results: The results showed that changes in collimator angle significantly affected CI, GI, normal liver V10 and V30, spinal cord D0.03 cm3, and monitor units, with statistically significant differences (all P< 0.05). However, no significant differences were observed in normal liver V20, mean liver dose, or γ pass rate (all P> 0.05). Conclusion: Collimator angle selection can optimize target dose distribution and reduce normal tissue irradiation, offering valuable clinical guidance for SRT plan design in liver cancer. Reference | Related Articles | Metrics